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논문 기본 정보

자료유형
학술저널
저자정보
Kim Ji-Eun (Department of Internal Medicine Inha University Hospital Incheon Republic of Korea.) Hwang Seun Deuk (Division of Nephrology and Hypertension Department of Internal Medicine Inha University College of Medicine Incheon Republic of Korea.) Lee Seoung Woo (Division of Nephrology and Hypertension Department of Internal Medicine Inha University College of Medicine Incheon Republic of Korea.) Song Joon Ho (Division of Nephrology and Hypertension Department of Internal Medicine Inha University College of Medicine Incheon Republic of Korea.) Kim Kipyo (Division of Nephrology and Hypertension Department of Internal Medicine Inha University College of Medicine Incheon Republic of Korea.)
저널정보
전해질고혈압연구회 Electrolytes & Blood Pressure Electrolytes & Blood Pressure Vol.20 No.1
발행연도
2022.6
수록면
17 - 20 (4page)
DOI
10.5049/EBP.2022.20.1.17

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Nicorandil is an anti-anginal drug that is commonly used in the treatment of ischemic heart disease. Nicorandil acts as a nitrate donor and ATP-sensitive potassium channel agonist, inducing coronary artery vasodilation. Potassium efflux through ATP-sensi tive potassium channels activated by nicorandil can cause refractory hyperkale mia, particularly in patients with chronic kidney disease (CKD). Here, we report the case of an 85-year-old man who presented with severe refractory hyperkalemia, despite proper medical management. His serum potassium level increased from 4.96 to 7.21 mEq/L 7 days after restarting nicorandil. Hyperkalemia resolved shortly after discontinuation of nicorandil, which was presumed to be the offending drug. Previously, a few cases reported nicorandil-induced hyperkalemia called potassium channel syndrome in patients with CKD, and hyperkalemia can be reversed by ceasing nicorandil or using sulfonyl urea drugs. Given that CKD patients may have several contributing factors to this adverse event, clinicians should be aware of the risk of nicorandil-induced hyperkalemia, and medication review and drug discontinuation should be considered.

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