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자료유형
학술저널
저자정보
김종훈 (Department of Dermatology and Allergology Juntendo University Graduate School of Medicine Tokyo) Toshio Hasegawa (Department of Dermatology and Allergology Juntendo University Graduate School of Medicine Tokyo) Kurisu Tada (Department of Rheumatology and Internal Medicine Juntendo University Graduate School of Medicine Tokyo) Yuki Uehara (Department of General Medicine Juntendo University Graduate School of Medicine Tokyo) Yukiko Fukui (Department of General Medicine Juntendo University Graduate School of Medicine Tokyo) Ayako Nakamura (Department of Clinical Laboratory Medicine Juntendo University Graduate School of Medicine Tokyo) Satomi Takei (Department of Clinical Laboratory Medicine Juntendo University Graduate School of Medicine Tokyo) Satoshi Mitarai (Department of Mycobacterium Reference and Research the Research Institute of Tuberculosis Japan Anti-Tuberculosis Association Tokyo) Akio Aono (Department of Mycobacterium Reference and Research the Research Institute of Tuberculosis Japan Anti-Tuberculosis Association Tokyo) Shigaku Ikeda (Department of Dermatology and Allergology Juntendo University Graduate School of Medicine Tokyo)
저널정보
대한피부과학회 Annals of Dermatology Annals of Dermatology 제35권
발행연도
2023.5
수록면
63 - 66 (4page)

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A 38-year-old female with systemic lupus erythematosus (SLE) initiated belimumab treat- ment. One month later, she presented with a reddish painful swelling on her right lower leg. She was treated with ceftriaxone and vancomycin. However, novel erythematous papules and indurated nodules appeared on both her lower legs. Skin biopsy revealed microabscess formation with mixed cell granuloma surrounded by inf lammatory cell infiltration within the dermis with subcutaneous fat tissue. A large number of acid-fast bacilli were observed with Ziehl–Neelsen staining. DNA sequencing of both the hsp65 and the 16S rRNA se- quences showed a 100% match with the corresponding region of Mycobacterium hae- mophilum . Mycobacterial culture revealed satellite growth enhancement on Middlebrook 7H11 agar plates around a paper strip containing hemin. She was treated with levof loxacin, rifabutin, and ethambutol. Within 13 months, her cutaneous lesions improved markedly without any side effects. The B cell-targeted biologic belimumab, a fully humanized IgG1γ monoclonal antibody that inactivates B lymphocyte stimulator, has been considered to be beneficial for active SLE. However, this therapy could increase the risk for the development of biologic therapy-associated mycobacterial infections, both tuberculosis and nontubercu- lous mycobacteria infections.

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