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논문 기본 정보

자료유형
학술저널
저자정보
Hong Cui (Department of Dermatology First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin) Zhijuan Mu (Department of Dermatology First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin)
저널정보
대한피부과학회 Annals of Dermatology Annals of Dermatology 제35권 제1호
발행연도
2023.2
수록면
11 - 22 (12page)
DOI
https://doi.org/10.5021/ad.21.268

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초록· 키워드

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Background: The gestational risk factors predispose to the manifestation of early childhoodatopic dermatitis (AD). Objective: We evaluated the association between modifiable and non-modifiable gestationaland prenatal risk factors that affect the AD prevalence in children. Methods: We performed the systematic review and meta-analysis of cohort studies (n=27) inPubMed and EMBASE (2000~2021). A meta-analysis was performed using random-effectsmodels to estimate pooled odds ratios (OR) or hazard ratio (HR). We performed a systematicreview according to Preferred Reporting Item for Systematic Review and Meta-Analyses(PRISMA) guidelines and summarized cohort studies investigating gestational and prenatalrisk factor those predispose to AD in off spring. Leading modifiable and non-modifiablewere identified through ORs. Meta-analysis using the random effect model was also conductedto provide an overall estimate for several significant factors. Results: Among the non-modifiable risk factors gestational diabetes (7.2, 95% confidence interval[CI]: 1.4~34.5), maternal history of allergy (2.14, 95% CI: 1.54~2.97) and prenatal history ofeczema (2.46, 95% CI: 1.0~5.8) were found as major determining risk factors in early manifestationof AD in children. Further, maternal exposure to industrial products (1.89, 95% CI: 1.10~3.16),exposure to antibiotics during pregnancy (3.59, 95% CI: 1.19~10.85) and passive smoking duringpregnancy (2.60, 95% CI: 1.11~6.1) are leading causes of early AD manifestation. Conclusion: Conclusively, both genetic and environmental factors play a pivotal role in earlymanifestation of AD. The better managing the environmental factors during gestationalphase to the least can help curtail the prevalence of AD in children.

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