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논문 기본 정보

자료유형
학술저널
저자정보
Lee Seung Won (Institute of Pharmaceutical Science Korea University Sejong Korea.) Kim Hayeon (College of Pharmacy Korea University Sejong Korea.) Byun Youngjoo (Institute of Pharmaceutical Science Korea University Sejong Korea.College of Pharmacy Korea University Sejong Korea.) Baek Yoo Sang (Department of Dermatology Guro Hospital Korea University College of Medicine Seoul Korea.) Choi Cheol Ung (Cardiovascular Center Guro Hospital Korea University College of Medicine Seoul Korea.) Kim Jae Hyun (School of Pharmacy and Institute of New Drug Development Jeonbuk National University Jeonju Korea.) Kim Kyungim (Institute of Pharmaceutical Science Korea University Sejong Korea.College of Pharmacy Korea University Sejong Korea.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.15 No.2
발행연도
2023.3
수록면
231 - 245 (15page)
DOI
10.4168/aair.2023.15.2.231

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Purpose: Despite increasing evidence for the potential association between atopic dermatitis (AD) and cardiovascular diseases (CVDs), results have still remained controversial. Therefore, this study investigated the association between AD and subsequent CVDs in adults newly diagnosed with AD. Methods: Datasets from the National Health Insurance Service-National Sample Cohort in South Korea from 2002 to 2015 were analyzed. The primary outcome was new-onset CVD, which included angina pectoris, myocardial infarction, stroke, or any revascularization procedure. The crude and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated in the AD group compared with the matched control group using the Cox proportional hazards regression models. Results: A total of 40,512 individuals with AD were matched with 40,512 control subjects without AD. The overall incidence of CVDs was 2,235 (5.5%) and 1,640 (4.1%) in the AD and matched control groups, respectively. In the adjusted model, AD was associated with an increased risk of CVDs (HR, 1.42; 95% CI, 1.33–1.52), angina pectoris (adjusted HR, 1.49; 95% CI, 1.36–1.63), myocardial infarction (adjusted HR, 1.40; 95% CI, 1.15–1.70), ischemic stroke (adjusted HR, 1.34; 95% CI, 1.20–1.49), and hemorrhagic stroke (adjusted HR, 1.26; 95% CI, 1.05–1.52). Most of the subgroup and sensitivity analysis results were consistent with those of the main analysis. Conclusions: The current study found that adult patients newly diagnosed with AD were at significantly increased risk for subsequent CVDs, suggesting the need to consider early prevention strategies for CVDs targeting patients with AD.

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