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논문 기본 정보

자료유형
학술저널
저자정보
Park Jaeil (School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST)) NGUYEN THI THUY CHAU (충남대학교) Lee Su-Jin (Department of Polymer Science and Engineering Graduate School of Chungnam National University) Wang Sungrok (School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST)) Heo Dongmi (School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST)) Kang Dong-Hee (School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST)) Tipan-Quishpe Alexander (School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST)) Lee Won-June (School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST)) Lee Jongwon (School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST)) Yang Sung Yun (Department of Polymer Science and Engineering Graduate School of Chungnam National University) Yoon Myung-Han (School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST))
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
693 - 706 (14page)
DOI
10.1186/s40824-023-00344-3

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Hydrogels have been widely used in many research fields owing to optical transparency, good biocompatibility, tunable mechanical properties, etc. Unlike typical hydrogels in the form of an unstructured bulk material, we developed aqueous dispersions of fiber-shaped hydrogel structures with high stability under ambient conditions and their application to various types of transparent soft cell culture interfaces with anisotropic nanoscale topography.Nanofibers based on the polyvinyl alcohol and polyacrylic acid mixture were prepared by electrospinning and hydrogelified to nano-fibrous hydrogels (nFHs) after thermal crosslinking and sulfuric acid treatment. By modifying various material surfaces with positively-charged polymers, negatively-charged superabsorbent nFHs could be selectively patterned by employing micro-contact printing or horizontally aligned by applying shear force with a wired bar coater.The angular distribution of bar-coated nFHs was dramatically reduced to ± 20° along the applied shear direction unlike the drop-coated nFHs which exhibit random orientations. Next, various types of cells were cultured on top of transparent soft nFHs which showed good viability and attachment while their behaviors could be easily monitored by both upright and inverted optical microscopy. Particularly, neuronal lineage cells such as PC 12 cells and embryonic hippocampal neurons showed highly stretched morphology along the overall fiber orientation with aspect ratios ranging from 1 to 14. Furthermore, the resultant neurite outgrowth and migration behaviors could be effectively controlled by the horizontal orientation and the three-dimensional arrangement of underlying nFHs, respectively.We expect that surface modifications with transparent soft nFHs will be beneficial for various biological/biomedical studies such as fundamental cellular studies, neuronal/stem cell and/or organoid cultures, implantable probe/device coatings, etc.
#Nano-fbrous hydrogel #Hydrogel dispersion #Bar coating #Self-alignment #Neuronal culture

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