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논문 기본 정보

자료유형
학술저널
저자정보
Haomeng Zhang (Shandong University Jinan China) Meng Zhang (Shandong First Medical University & Shandong Academy of Medical Sciences Jinan China) Xinyu Zhang (Shandong First Medical University & Shandong Academy of Medical Sciences Jinan China) Yuan Gao (Shandong First Medical University & Shandong Academy of Medical Sciences Jinan China) Yanling Ma (National University of Singapore Singapore) Hongyu Chen (Shandong First Medical University & Shandong Academy of Medical Sciences Jinan China) Jipeng Wan (Shandong University Jinan China) Changzhong Li (Shandong Provincial Hospital Affiliated to Shandong University) Fei Wang (Shandong University Jinan China) Xiao Sun (Shandong Cancer Hospital affiliated to Shandong University Shandong Academy of Medical Sciences)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제26권 제2호
발행연도
2022.6
수록면
154 - 175 (22page)
DOI
https://doi.org/10.1186/s40824-022-00268-4

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Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability and undesirable systemic toxicity. Polymeric hydrogels with a three-dimensional network structure enable on-site delivery and controlled release of therapeutic drugs with reduced systemic toxicity and have been widely developed for postoperative adjuvant tumor therapy. Among them, because of the simple synthesis, good biocompatibility, biodegradability, injectability, and multifunctionality, iron based hydrogels have received extensive attention. This review has summarized the general synthesis methods and construction principles of iron-based hydrogels, highlighted the latest progress of iron-based hydrogels in postopera tive tumor therapy, including chemotherapy, photothermal therapy, photodynamic therapy, chemo-dynamic therapy, and magnetothermal-chemical combined therapy, etc. In addition, the challenges towards clinical application of iron-based hydrogels have also been discussed. This review is expected to show researchers broad perspectives of novel postoperative tumor therapy strategy and provide new ideas in the design and application of novel iron-based hydrogels to advance this sub field in cancer nanomedicine.

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