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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 157 - 164 (8page)
- DOI
- https://doi.org/10.1186/s40824-017-0110-x
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초록· 키워드
오류제보하기
Background: An electrically conductive hydrogel has emerged to regulate cellular secretion activities with electrical stimulation. However, the electrical conductivity of typical hydrogel systems decreases with increasing elastic modulus of the hydrogels because of decreased transport of ions through a polymeric cross-linked mesh. Method: This study hypothesized that the inverse dependency between electrical conductivity and elastic modulus would be made through the cross-linking of conductive monomer-units conjugated to a hydrophilic polymeric backbone. This hypothesis was examined through the cross-linking of pyrrole groups that were conjugated to an alginate backbone, termed alginate-g-pyrrole. Results: Hydrogels with increased degrees of pyrrole substitution exhibited a simultaneous increase in the gels mechanical rigidity and electrical conductivity. The resulting hydrogel could control the adhesion and vascular endothelial growth factor secretion of cells via applied electrical stimulation. Conclusions: This material design principle will be broadly useful to fabricating materials used for various actuation, cell culture, and biomedical applications.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
DeVolder RJ / 2011 / Modulating the rigidity and mineralization of collagen gels using poly(lactic-co-glycolic acid)microparticles / Tissue Eng 18:1642
DeVolder RJ / 2010 / Three dimensionally flocculated proangiogenic microgels for neovascularization / Biomaterials 31:6494~6501
DeVolder RJ / 2012 / Hydrogels for in vivo-like three-dimensional cellular studies / WIREs Syst Biol Med 4:351~365
DeVolder RJ / 2011 / blood vessel growth using an angiogenic microfiber/microparticle composite patch / Adv Mater 23:3139~3143
Chan G / 2008 / New materials for tissue engineering: towards greater control over the biological response / Trends Biotechnol 26:382~392
DeVolder RJ / 2010 / Three dimensionally flocculated proangiogenic microgels for neovascularization / Biomaterials 31:6494~6501
DeVolder RJ / 2012 / Hydrogels for in vivo-like three-dimensional cellular studies / WIREs Syst Biol Med 4:351~365
DeVolder RJ / 2011 / blood vessel growth using an angiogenic microfiber/microparticle composite patch / Adv Mater 23:3139~3143
Chan G / 2008 / New materials for tissue engineering: towards greater control over the biological response / Trends Biotechnol 26:382~392
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