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논문 기본 정보

자료유형
학술저널
저자정보
위정희 (가톨릭대학교) Yoo Ki-Dong (Division of Cardiology Department of Internal Medicine St. Vincent’s Hospital) Sim Sung Bo (The Catholic University) Kim Hyun Joo (Institute of Cell and Tissue Engineering College of Medicine The Catholic University of Korea) 김한준 (가톨릭대학교) Park Kyu Nam (Department of Emergency Medicine The Catholic University of Korea) Kim Gee-Hee (Division of Cardiology Department of Internal Medicine St. Vincent’s Hospital) 문미형 (가톨릭대학교) You Su Jung (Institute of Cell and Tissue Engineering College of Medicine The Catholic University of Korea) Ha Mi Yeon (Institute of Cell and Tissue Engineering College of Medicine The Catholic University of Korea) 양대혁 (가톨릭대학교) Chun Heung Jae (Institute of Cell and Tissue Engineering College of Medicine The Catholic University of Korea) Ko Jae Hoon (Smart Textiles R&D group Korea Institute of Industrial Technology (KITEC)) Kim Chun Ho (Laboratory of Tissue Engineering Korea Institute of Radiological and Medical Sciences)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
134 - 150 (17page)
DOI
10.1186/s40824-022-00319-w

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Background : Although the use of cardiac patches is still controversial, cardiac patch has the significance in the field of the tissue engineered cardiac regeneration because it overcomes several shortcomings of intra-myocardial injection by providing a template for cells to form a cohesive sheet. So far, fibrous scaffolds fabricated using electrospinning technique have been increasingly explored for preparation of cardiac patches. One of the problems with the use of electrospinning is that nanofibrous structures hardly allow the infiltration of cells for development of 3D tissue construct. In this respect, we have prepared novel bi-modal electrospun scaffolds as a feasible strategy to address the challenges in cardiac tissue engineering. Methods : Nano/micro bimodal composite fibrous patch composed of collagen and poly (D, L-lactic-co-glycolic acid) (Col/PLGA) was fabricated using an independent nozzle control multi-electrospinning apparatus, and its feasibility as the stem cell laden cardiac patch was systemically investigated. Results : Nano/micro bimodal distributions of Col/PLGA patches without beaded fibers were obtained in the range of the 4-6% collagen concentration. The poor mechanical properties of collagen and the hydrophobic property of PLGA were improved by co-electrospinning. In vitro experiments using bone marrow-derived mesenchymal stem cells (BMSCs) revealed that Col/PLGA showed improved cyto-compatibility and proliferation capacity compared to PLGA, and their extent increased with increase in collagen content. The results of tracing nanoparticle-labeled as well as GFP transfected BMSCs strongly support that Col/PLGA possesses the long-term stem cells retention capability, thereby allowing stem cells to directly function as myocardial and vascular endothelial cells or to secrete the recovery factors, which in turn leads to improved heart function proved by histological and echocardiographic findings. Conclusion : Col/PLGA bimodal cardiac patch could significantly attenuate cardiac remodeling and fully recover the cardiac function, as a consequence of their potent long term stem cell engraftment capability.
#Nano and micro bimodal fbrous scafold #Cardiac patch #Collagen #PLGA #BMSCs #Myocardial regeneration

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