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Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia
Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국생체재료학회 생체재료학회지 생체재료학회지 제23권 제4호 KCI Accredited Journals
- 발행연도
- 2019.1
- 수록면
- 218 - 227 (10page)
이용수
Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia
초록· 키워드
오류제보하기
Background: Alopecia has become a very common disease that many people around the world are suffered. Minoxidil (MXD) is the most well-known commercialized drug in its treatment. However, in the case of MXD administration, there are some problems with low efficiency of transdermal delivery and additional side effects. Method: MXD and Rhodamine B (Rho B) are encapsulated in poly(Lactide-co-Glycolide) grafted hyaluronate nanoparticles (HA-PLGA/MXD NPs, HA-PLGA/Rho B NPs) which is prepared with W/O/W solvent evaporation method. After then, the investigation is carried out to confirm the feasibility of NPs in alopecia treatment. Results: Both of HA-PLGA/MXD NPs and HA-PLGA/Rho B NPs are successfully prepared. In addition, it is confirmed that HA-PLGA NPs sufficiently delivered to cells without any significant cytotoxicity by cell viability, cellular uptake and skin permeation test. Conclusion: Taken together, HA-PLGA NPs as a transdermal delivery carrier to hair follicle cells can be exploited to develop the efficient and effective platform of transdermal drug delivery for the treatment of various diseases.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Messenger AG / 2004 / Minoxidil : mechanisms of action on hair growth / Br J Dermatol 150:186~194
Pratt CH / 2017 / Alopecia areata / Nat Rev Dis Primers 3:17011
Yang G / 2019 / A therapeutic microneedle patch made from hair-derived keratin for promoting hair regrowth / ACS Nano 13:4354~4360
이효중 / 2017 / Preparation and in vivo evaluation of lecithin-based microparticles for topical delivery of minoxidil / Archives of Pharmacal Research 40(8):943~951
Jimenez MG / 2011 / Aromatic C-nitrosation of bioactive molecule. Nitrosation of minoxidil / Org Biomol Chem 9:7680
Pratt CH / 2017 / Alopecia areata / Nat Rev Dis Primers 3:17011
Yang G / 2019 / A therapeutic microneedle patch made from hair-derived keratin for promoting hair regrowth / ACS Nano 13:4354~4360
이효중 / 2017 / Preparation and in vivo evaluation of lecithin-based microparticles for topical delivery of minoxidil / Archives of Pharmacal Research 40(8):943~951
Jimenez MG / 2011 / Aromatic C-nitrosation of bioactive molecule. Nitrosation of minoxidil / Org Biomol Chem 9:7680
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