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Subject

Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications
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논문 기본 정보

Type
Academic journal
Author
Rajendran JC Bose (Chung-Ang University) Soo-Hong Lee (차의과학대학교) Hansoo Park (중앙대학교)
Journal
한국생체재료학회 생체재료학회지 생체재료학회지 제20권 제4호 KCI Accredited Journals
Published
2016.12
Pages
213 - 221 (9page)
DOI
10.1186/s40824-016-0081-3

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Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications
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Abstract· Keywords

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The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, and nonspecific tissue distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of PLGA-based clinical nanomedicines. Surface engineering with different lipids enhances the target specificity of the carrier and improves its physicochemical properties as well as NP-cell associations, such as cellular membrane permeability, immune responses, and long circulation half-life in vivo. This review focuses on recent advances in the lipid-based surface engineering of PLGA NPs for drug and gene delivery applications.

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