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논문 기본 정보

자료유형
학술저널
저자정보
Sungchul Choi (Yonsei University College of Medicine) Beom Kyung Kim (Department of Internal Medicine Yonsei University College of Medicine Seoul; Institute of Gastroenterology Yonsei University College of Medicine Seoul; Yonsei Liver Center Severance Hospital Yonsei Un) Dong Keon Yon (Department of Pediatrics Kyung Hee University Medical Center Kyung Hee University College of Medicine) Seung Won Lee (Department of Precision Medicine Sungkyunkwan University School of Medicine Suwon Gyeonggi-do Korea) Han Gyeol Lee (Yonsei University College of Medicine) Ho Hyeok Chang (Yonsei University College of Medicine) Seoyeon Park (Yonsei University College of Medicine) Ai Koyanagi (Research and Development Unit Parc Sanitari Sant Joan de Déu CIBERSAM Dr. Antoni Pujadas Barcelona; Catalan Institution for Research and Advanced Studies Pg. Lluis Companys 23) Louis Jacob (Research and Development Unit Parc Sanitari Sant Joan de Déu CIBERSAM Dr. Antoni Pujadas Barcelona; Department of Physical Medicine and Rehabilitation Lariboisière-Fernand Widal Hospital AP-HP Univers) Elena Dragioti (Pain and Rehabilitation Centre and Department of Health Medicine and Caring Sciences Linkoping University) Joaquim Radua (Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) CIBERSAM Instituto de Salud Carlos III University of Barcelona Barcelona Spain; Centre for Psychiatric Research Department of Clinica) Jae Il Shin (Department of Pediatrics Yonsei University College of Medicine) Seung Up Kim (Department of Internal Medicine Yonsei University College of Medicine Seoul; Institute of Gastroenterology Yonsei University College of Medicine Seoul; Yonsei Liver Center Severance Hospital Yonsei Un) Lee Smith (Centre for Health Performance and Wellbeing Anglia Ruskin University)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제29권 제2호
발행연도
2023.4
수록면
433 - 452 (20page)

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초록· 키워드

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Background/Aims: Global distribution of dominant liver cancer aetiologies has significantly changed over the past decades. This study analyzed the updated temporal trends of liver cancer aetiologies and sociodemographic status in 204 countries and territories from 1990 to 2019. Methods: The Global Burden of Disease 2019 report was used for statistical analysis. In addition, we performed stratification analysis to five quintiles using sociodemographic index and 21 geographic regions. Results: The crude numbers of liver cancer disease-adjusted life years (DALYs) and deaths significantly increased during the study period (DALYs; 11,278,630 in 1990 and 12,528,422 in 2019, deaths; 365,215 in 1990 and 484,577 in 2019). However, the Age-standardized DALY and mortality rates decreased. Hepatitis B virus (HBV) remains the leading cause of liver cancer DALYs and mortality, followed by hepatitis C virus (HCV), alcohol consumption, and non-alcoholic steatohepatitis/non-alcoholic fatty liver disease (NASH/NAFLD). Although Age-standardized DALY and mortality rates of liver cancer due to HBV and HCV have decreased, the rates due to alcohol consumption and NASH/NAFLD have increased. In 2019, the population of the East Asia region had the highest Age-standardized DALY and mortality rates, followed by high-income Asia-Pacific and Central Asia populations. Although East Asia and high-income Asia-Pacific regions showed a decrease during the study period, Age-standardized DALY rates increased in Central Asia. High-income North American and Australasian populations also showed a significant increase in Age-standardized DALY. Conclusions: Liver cancer remains an ongoing global threat. The burden of liver cancer associated with alcohol consumption and NASH/NAFLD is markedly increasing and projected to continuously increase.

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