지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 406 - 422 (17page)
이용수
초록· 키워드
오류제보하기
Sarcopenia is an age-related, progressive skeletal muscle disorder involving the loss of muscle mass and strength. Previous studies have shown that γ-aminobutyric acid (GABA) from fermented oysters aids in regulatory T cells (Tregs) cell expansion and function by enhancing autophagy, and concomitantly mediate muscle regeneration by modulating muscle inflammation and satellite cell function. The fermentation process of oysters not only increases the GABA content but also enhances the content of branched amino acids and free amino acids that aid the level of protein absorption and muscle strength, mass, and repair. In this study, the effect of GABA-enriched fermented sarco oyster extract (FSO) on reduced muscle mass and functions via Treg modulation and enhanced autophagy in aged mice was investigated. Results showed that FSO enhanced the expression of autophagy markers (autophagy-related gene 5 [ATG5] and GABA receptor-associated protein [GABARAP]), forkhead box protein 3 (FoxP3) expression, and levels of anti-inflammatory cytokines (interleukin [IL]-10 and transforming growth factor [TGF]-β) secreted by Tregs while reducing pro-inflammatory cytokine levels (IL-17A and interferon [IFN]-γ). Furthermore, FSO increased the expression of IL-33 and its receptor IL-1 receptor-like 1 (ST2); well-known signaling pathways that increase amphiregulin (Areg) secretion and expression of myogenesis markers (myogenic factor 5, myoblast determination protein 1, and myogenin). Muscle mass and function were also enhanced via FSO. Overall, the current study suggests that FSO increased autophagy, which enhanced Treg accumulation and function, decreased muscle inflammation, and increased satellite cell function for muscle regeneration and therefore could decrease the loss of muscle mass and function with aging.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Studies of Natural Small-Molecule Compounds Modulating the Aging of Muscle and Muscle Stem Cells
한국식품영양과학회 학술대회발표집
2021 .10
-
Meeting the meat: delineating the molecular machinery of muscle development
한국축산학회지
2016 .01
-
Comparative review of muscle fiber characteristics between porcine skeletal muscles
한국축산학회지
2024 .03
-
The Effects of Marine Algal Polyphenols on Muscle Growth in C2C12 Muscle Cells through Myogenesis Pathways
한국식품영양과학회 학술대회발표집
2018 .10
-
Silver and Sport Product Development for Muscle Loss Prevention and Muscle Strengthening
한국식품영양과학회 학술대회발표집
2017 .10
-
Agastache rugosa Kuntze Extract Attenuates Muscle Atrophy by Regulating the Protein Turnover and Differentiation in C2C12 Myotubes
한국식품영양과학회 학술대회발표집
2021 .10
-
Inhibition of p38 in chicken muscle stem cells affects proliferation and differentiation to muscle
한국가금학회 정기총회 및 학술발표회
2021 .11
-
Nutritional Management for the Prevention of Muscle Loss
한국식품영양과학회 학술대회발표집
2021 .10
-
Overview of muscle metabolism, muscle fiber characteristics, and meat quality
Korean Journal of Agricultural Science
2018 .03
-
근위축 마우스 모델에서 한국산 겨우살이 추출물에 의한 단백질 합성 신호전달 경로의 활성화
한국식품영양학회지
2017 .04
-
Inhibitory Effect of Red Bean Extract on TNF-α-induced Muscle Atrophy in Skeletal Muscle Cells
한국식품영양과학회 학술대회발표집
2016 .10
-
Chrysanthemum morifolium Extract Improves Muscle Function through Increasing Mitochondrial Biogenesis and Muscle Protein Synthesis
한국식품영양과학회 학술대회발표집
2018 .10
-
Simvastatin이 메추리 근육 세포에 미치는 영향
한국가금학회지
2022 .12
-
Amelioration of Muscle Wasting by C-Peptide in Glucocorticoid-Induced Skeletal Muscle Atrophy
한국식품영양과학회 학술대회발표집
2021 .10
-
The Role of Protein Intake in Preserving Skeletal Muscle Mass in Older Adults
한국식품영양과학회 학술대회발표집
2017 .10
-
Fermented oyster extract attenuates dexamethasone-induced muscle atrophy via PI3K/Akt/mTOR pathway in C2C12 myoblasts
한국식품영양과학회 학술대회발표집
2022 .10
-
Development of Plant-Based Protein for Preventing Sarcopenia and Muscle Strength Improvement
한국식품영양과학회 학술대회발표집
2022 .10
-
노화 쥐 모델에서 상엽과 신선초 복합추출물이 근 위축에 미치는 영향
한국식품영양과학회지
2025 .03
-
Fermented Whey Protein Isolate by Lactobacillus gasseri IM13 Prevents Dexamethasone-Induced Muscle Atrophy in Muscle Cell
한국식품영양과학회 학술대회발표집
2022 .10
-
Regulation of adductor muscle growth by the IGF-1/AKT pathway in the triploid Pacific oyster, Crassostrea gigas
Fisheries and Aquatic Sciences
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0