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논문 기본 정보

자료유형
학술저널
저자정보
Heo Namwoo (Division of Infectious diseases Department of Internal Medicine Yongin Severance Hospital Yonsei University College of Medicine Yongin Korea.Division of Disease Control Policy Gyeonggi Provincial Gove) Lee Jihee (Korea Disease Control and Prevention Agency Cheongju Korea.) Kim Yeonkyung (Gyeonggi Infectious Disease Control Center Suwon Korea.) Lee Donghan (Korea Disease Control and Prevention Agency Cheongju Korea.) Heo Seok-Jae (Division of Biostatistics Department of Biomedical Systems Informatics Yonsei University College of Medicine Seoul Korea.) Park Yoon Soo (Division of Infectious diseases Department of Internal Medicine Yongin Severance Hospital Yonsei University College of Medicine Yongin Korea.) Yun Jae-Won (Korea Disease Control and Prevention Agency Cheongju Korea.) Kim Yong Chan (Division of Infectious diseases Department of Internal Medicine Yongin Severance Hospital Yonsei University College of Medicine Yongin Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.38 No.15
발행연도
2023.4
수록면
1 - 11 (11page)
DOI
10.3346/jkms.2023.38.e117

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Background: The largest outbreak of enterohemorrhagic Escherichia coli (EHEC) O157:H7 occurred at a preschool in South Korea from June 12 to 29, 2020. This study aimed to analyze the epidemiological and clinical characteristics of EHEC infection in this outbreak. Methods: Epidemiological investigation was performed on all 184 children and 19 workers at the preschool using a standard questionnaire to assess symptoms, food intake, attendance, and special activity history. Pulsed-field gel electrophoresis analysis of confirmed cases was performed to determine genetic relevance. Results: During this outbreak, 103 children were affected, whereas only one infection was identified in adults. Of the 103 pediatric patients, 85 had symptoms (82.5%), including diarrhea, abdominal pain, bloody stool, fever, and vomiting. Thirty-two patients (31.1%) were hospitalized, 15 (14.6%) were diagnosed with hemolytic uremic syndrome, and 4 (3.9%) received dialysis treatment. Pulsed-field gel electrophoresis analysis identified 4 genotypes with high genetic relevance (92.3%). Epidemiological investigation revealed that this outbreak might have occurred from ingesting foods stored in a refrigerator with a constant temperature above 10°C, which was conducive to bacterial growth. Despite several measures after outbreak recognition, new infections continued to appear. Therefore, the preschool was forced to close on June 19 to prevent further person-to-person transmission. Conclusion: Our findings from the response to the largest outbreak will help prepare countermeasures against future EHEC outbreak.

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