지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.2
- 수록면
- 401 - 412 (12page)
- DOI
- 10.1038/s12276-023-00945-x
이용수
초록· 키워드
오류제보하기
Endoplasmic reticulum stress is closely associated with the onset and progression of inflammatory bowel disease. ERdj5 is an endoplasmic reticulum-resident protein disulfide reductase that mediates the cleavage and degradation of misfolded proteins. Although ERdj5 expression is significantly higher in the colonic tissues of patients with inflammatory bowel disease than in healthy controls, its role in inflammatory bowel disease has not yet been reported. In the current study, we used ERdj5-knockout mice to investigate the potential roles of ERdj5 in inflammatory bowel disease. ERdj5 deficiency causes severe inflammation in mouse colitis models and weakens gut barrier function by increasing NF-κB-mediated inflammation. ERdj5 may not be indispensable for goblet cell function under steady-state conditions, but its deficiency induces goblet cell apoptosis under inflammatory conditions. Treatment of ERdj5-knockout mice with the chemical chaperone ursodeoxycholic acid ameliorated severe colitis by reducing endoplasmic reticulum stress. These findings highlight the important role of ERdj5 in preserving goblet cell viability and function by resolving endoplasmic reticulum stress.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Inhibition of Endoplasmic Reticulum Stress-induced Apoptosis by Silkworm Storage Protein 1
한국생물공학회 학술대회
2019 .04
-
Anti-Endoplasmic Reticulum Stress induced Apoptosis by Silkworm Storage Protein 1, SP1
한국생물공학회 학술대회
2018 .10
-
Tailoring the Saccharomyces cerevisiae Endoplasmic Reticulum for Functional Assembly of Terpene Synthesis Pathway
한국생물공학회 학술대회
2023 .10
-
Tailoring the Saccharomyces cerevisiae Endoplasmic Reticulum for Functional Assembly of Terpene Synthesis Pathway
한국생물공학회 학술대회
2020 .10
-
Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications
한국고분자학회 학술대회 연구논문 초록집
2017 .04
-
FB1 Induced Endoplasmic Reticulum Stress As a Progression Factor for Kidney Injury
한국생물공학회 학술대회
2015 .04
-
Development of Anti-inflammatory Aptamers for Inhibiting Inflammatory Bowel Disease
한국생물공학회 학술대회
2023 .04
-
Enhanced production of Recombinant antibody by various Antioxidants in rCHO cell culture
한국생물공학회 학술대회
2019 .04
-
Harnessing Yeast Endoplasmic Reticulum for High-level Production of Value-added Biochemicals
한국생물공학회 학술대회
2022 .04
-
Editorial Expression of Concern: Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction
Experimental and Molecular Medicine
2021 .04
-
Highly Sensitive Carbon Nanotube-based Sensors for the Detection of Cytokines in Inflammatory Bowel Diseases
대한기계학회 춘추학술대회
2016 .05
-
Overcoming Multidrug Resistance by Activating Unfolded Protein Response of the Endoplasmic Reticulum in Cisplatin-Resistant A2780/CisR Ovarian Cancer Cells
BMB Reports
2020 .01
-
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling
Experimental and Molecular Medicine
2021 .02
-
Metabolic Engineering of Gut Microorganism for Production of Colitis Attenuating Agents
한국생물공학회 학술대회
2023 .10
-
Differential effects of PM2.5 and PM10 on cell viability, inflammatory responses, and oxidative stress in cultured corneal epithelial cells
한국생물공학회 학술대회
2017 .10
-
Harnessing Cellular Organelles to Bring New Functionalities into Yeast
한국생물공학회 학술대회
2023 .10
-
Structural characterization of calmodulin like domain of ryanodine receptor type 1
Journal of the Korean Magnetic Resonance Society
2015 .01
-
Inhibition of LSD1 phosphorylation alleviates colitis symptoms induced by dextran sulfate sodium
BMB Reports
2020 .01
-
The interplay between host immune cells and gut microbiota in chronic inflammatory diseases
Experimental and Molecular Medicine
2017 .01
-
Relevance of the endoplasmic reticulum-mitochondria axis in cancer diagnosis and therapy
Experimental and Molecular Medicine
2024 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0