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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 88 - 93 (6page)
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Cisplatin is a widely used anti-cancer agent. However, the effectiveness of cisplatin has been limited by the commonly developed drug resistance. This study aimed to investigate the potential effects of endoplasmic reticulum (ER) stress to overcome drug resistance using the cisplatin-resistant A2780/CisR ovarian cancer cell model. The synthetic chalcone derivative (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (named DPP23) is an ER stress inducer. We found that DPP23 triggered apoptosis in both parental cisplatinsensitive A2780 and cisplatin-resistant A2780/CisR ovarian cancer cells due to activation of reactive oxygen species (ROS)-mediated unfolded protein response (UPR) pathway in the endoplasmic reticulum. This result suggests that ROSmediated UPR activation is potential in overcoming drug resistance. DPP23 can be used as a target pharmacophore for the development of novel chemotherapeutic agents capable of overcoming drug resistance in cancer cells, particularly ovarian cancer cells.
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참고문헌 (23)
참고문헌 신청
Moore WR / 1989 / Increased capacity for glutathione synthesis enhances resistance to radiation in Escherichia coli : a possible model for mammalian cell protection / Proc Natl Acad Sci U S A 86:1461~1464
Godwin AK / 1992 / High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis / Proc Natl Acad Sci U S A 89:3070~3074
Shin SY / 2014 / Targeting cancer cells via the reactive oxygen species-mediated unfolded protein response with a novel synthetic polyphenol conjugate / Clin Cancer Res 20:4302~4313
Adams DJ / 2012 / Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs / Proc Natl Acad Sci U S A 109:15115~15120
Cho HY / 2009 / Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress / Cancer Lett 282:87~97
Godwin AK / 1992 / High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis / Proc Natl Acad Sci U S A 89:3070~3074
Shin SY / 2014 / Targeting cancer cells via the reactive oxygen species-mediated unfolded protein response with a novel synthetic polyphenol conjugate / Clin Cancer Res 20:4302~4313
Adams DJ / 2012 / Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs / Proc Natl Acad Sci U S A 109:15115~15120
Cho HY / 2009 / Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress / Cancer Lett 282:87~97
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