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논문 기본 정보

자료유형
학술저널
저자정보
Bae-Gon Kang (Kyungpook National University) Eun-Ji Park (Kyungpook National University) So-Young Park (Kyungpook National University) Kwang-Hyeon Liu (Kyungpook National University)
저널정보
한국질량분석학회 Mass Spectrometry Letters Mass Spectrometry Letters Vol.13 No.4
발행연도
2022.12
수록면
152 - 157 (6page)

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Schisandra chinensis and its fruits have been used as a traditional herbal medicine to treat liver dysfunction, fatigue, and chronic coughs. Several in vitro and in vivo studies suggested that dibenzocyclooctadiene lignans present in Schisandra fruits strongly inhibit CYP3A4 activity. However, reports on the inhibitory potential of dietary Schisandra supplements against CYP3A activity are limited despite their increasing consumption as dietary supplements. In this study, we evaluated the CYP3Ainhibitory potential of four dietary Schisandra supplements in human liver microsomes. At a concentration of 0.05 mg/mL, Schisandra supplements from Nature’s Way, Swanson, Planetary Herbals, and Only Natural inhibited CYP3A activity by 93.9, 70.8, 33.6, and 24.8%, respectively. Nature’s Way, which exhibited the strongest inhibition against CYP3A, had the highest contents of gomisin B and gomisin C, which potently inhibit CYP3A activity. The in vivo pharmacokinetics of this product should be examined to determine whether the clinical relevance of inhibiting CYP3A activity by dietary Schisandra supplementation.

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Abstract
Introduction
Experimental
Results and Discussion
Conclusions
References

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