지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 180 - 187 (8page)
- DOI
- 10.7783/KJMCS.2023.31.3.180
이용수
초록· 키워드
오류제보하기
Background: Lilium dauricum Ker-Gawl is an endangered plant, and it is highly valued as a medicinal plant owing to its excellent functionality.
Methods and Results: L. dauricum leaf extract was shown to have high antioxidant activity and an inhibition concentration of 50% (IC<SUB>50</SUB>)value of 71.8 ± 0.13 ㎍/㎖ was shown for 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity. Its total phenol and flavonoid contents were 74.76 ± 0.24 ㎎·gallic acid equivalent (GAE)/g and 31.44 ± 0.27 ㎎·quercetin equivalent (QE)/g, respectively. Nitric oxide (NO) production was measured after oxidative stress was induced in lipopolysaccharide-stimulated RAW 264.7 cells, and 200 ㎍/㎖ of leaf extract effectively inhibited NO production at a rate of 17.84 ± 0.18%. Gastric cancer cells (AGS) and lung cancer cells (A549) were treated with 200 ㎍/㎖ of bulb extract, the inhibition rate for gastric cancer cell growth was 48.12 ± 2.60% whereas the inhibition rate for lung cancer cell growth was 55.83 ± 4.08%.
Conclusions: These results provide basic research data that can be used to identify the active constituents present in L. dauricum leaf and bulb extracts for the development of anticancer drugs, antioxidants, and functional products.
Methods and Results: L. dauricum leaf extract was shown to have high antioxidant activity and an inhibition concentration of 50% (IC<SUB>50</SUB>)value of 71.8 ± 0.13 ㎍/㎖ was shown for 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity. Its total phenol and flavonoid contents were 74.76 ± 0.24 ㎎·gallic acid equivalent (GAE)/g and 31.44 ± 0.27 ㎎·quercetin equivalent (QE)/g, respectively. Nitric oxide (NO) production was measured after oxidative stress was induced in lipopolysaccharide-stimulated RAW 264.7 cells, and 200 ㎍/㎖ of leaf extract effectively inhibited NO production at a rate of 17.84 ± 0.18%. Gastric cancer cells (AGS) and lung cancer cells (A549) were treated with 200 ㎍/㎖ of bulb extract, the inhibition rate for gastric cancer cell growth was 48.12 ± 2.60% whereas the inhibition rate for lung cancer cell growth was 55.83 ± 4.08%.
Conclusions: These results provide basic research data that can be used to identify the active constituents present in L. dauricum leaf and bulb extracts for the development of anticancer drugs, antioxidants, and functional products.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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