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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 194 - 198 (5page)
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A 60-year-old man diagnosed with unresectable hepatocellular carcinoma (HCC) presented to the hospital with pain in the perineal region. He had been taking lenvatinib every day for 2 months after he was diagnosed with HCC with metastases to the lymph node, small bowel mesentery, and retroperitoneal space. Enhanced abdominal computed tomography revealed mild elevation in intensity in the perineal subcutaneous tissue with subcutaneous emphysema. The patient was diagnosed with Common Terminology Criteria for Adverse Events grade 3, skin ulceration of stage IV with full-thickness skin loss and tissue necrosis in the muscular layer. The patient was taken off the medication with prescription of antibiotics, and after 3 weeks, the skin has fully recovered. This is the first report of an HCC patient who presented with a skin ulceration of stage IV after lenvatinib treatment. We recommend stopping the medication immediately and changing to alternative treatments with appropriate supportive care.
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참고문헌 (15)
참고문헌 신청
Dipasquale A / 2021 / A comparison of lenvatinib versus sorafenib in the first-line treatment of unresectable hepatocellular carcinoma : selection criteria to guide physician's choice in a new therapeutic scenario / J Hepatocell Carcinoma 8:241~251
Kudo M / 2018 / Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma : a randomised phase 3 noninferiority trial / Lancet 391:1163~1173
Yamashita T / 2020 / REFLECT-a phase 3 trial comparing efficacy and safety of lenvatinib to sorafenib for the treatment of unresectable hepatocellular carcinoma : an analysis of Japanese subset / J Gastroenterol 55:113~122
Liu Z / 2019 / Complete response to the combination of Lenvatinib and Pembrolizumab in an advanced hepatocellular carcinoma patient : a case report / BMC Cancer 19:1062
European Medicines Agency / Lenvima
Kudo M / 2018 / Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma : a randomised phase 3 noninferiority trial / Lancet 391:1163~1173
Yamashita T / 2020 / REFLECT-a phase 3 trial comparing efficacy and safety of lenvatinib to sorafenib for the treatment of unresectable hepatocellular carcinoma : an analysis of Japanese subset / J Gastroenterol 55:113~122
Liu Z / 2019 / Complete response to the combination of Lenvatinib and Pembrolizumab in an advanced hepatocellular carcinoma patient : a case report / BMC Cancer 19:1062
European Medicines Agency / Lenvima
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