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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Cellular FLIP (cFLIP; cellular FLICE inhibitory protein) is a key regulator of caspase-8 activity, and its viral homolog (vFLIP)is found in various viruses. cFLIP inhibits the caspase-8 activation in death-inducing signaling complex (DISC) when itsexpression level is high as in cancer cells. In contrast, cFLIP can also activate the caspase-8 in its lower expression leveland in lymphocyte in particular which results in the activation of NF-κB transcription factor. Recent biochemical studies onDISC has proposed that DED proteins in DISC, that are FADD, procaspase-8 & cFLIP, utilize two hydrophobic faces of theirDEDs for establishing DED-DED network for DISC assembly. Regarding the NF-κB activation, the crystal structure of K13-vFLIP showed that two grooves in the N-terminal DED in FLIP are the sites where dimeric IKKγ binds. FLIP is associatedwith various cancers seemingly through the dual functions of inhibiting apoptosis and promoting proliferation, so it wouldan attractive anti-cancer therapeutic target at either mRNA or protein level.
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참고문헌 (59)
참고문헌 신청
Bagneris, C. / 2008 / Crystal structure of a vFlip-IKKgamma complex : insights into viral activation of the IKK signalosome / Mol Cell 30:620~631
Bertin, J. / 1997 / Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas-and TNFR1-induced apoptosis / Proc Natl Acad Sci USA 94:1172~1176
Boldin, M. P. / 1996 / Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death / Cell 85:803~815
Carrington, P. E. / 2006 / The structure of FADD and its mode of interaction with procaspase-8 / Mol Cell 22:599~610
Cesarman, E. / 1995 / Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas / N Engl J Med 332:1186~1191
Bertin, J. / 1997 / Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas-and TNFR1-induced apoptosis / Proc Natl Acad Sci USA 94:1172~1176
Boldin, M. P. / 1996 / Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death / Cell 85:803~815
Carrington, P. E. / 2006 / The structure of FADD and its mode of interaction with procaspase-8 / Mol Cell 22:599~610
Cesarman, E. / 1995 / Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas / N Engl J Med 332:1186~1191
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