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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 245 - 252 (8page)
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Macrophage cell death contributes to the formation of plaque, leading to the development of atherosclerosis. The accumulation of triglyceride (TG) is also associated with the pathogenesis of atherosclerosis. A previous study reported that TG induces the cell death of macrophages. This study examined whether the cytoplasmic release of cathepsin B from lysosome is associated with the TG-induced cell death of macrophage. The release of cathepsin B was increased in the TG-treated THP-1 macrophages, but the TG treatment did not affect cathepsin B expression. Furthermore, the inhibition of cathepsin B by its inhibitor, CA-074 Me, partially inhibited the TG-induced cell death of macrophage. TG-triggered macrophage cell death is mediated by the activation of caspase-1, -2, and apoptotic caspases. Therefore, this study investigated whether cathepsin B is implicated in the activation of these caspases. The inhibition of cathepsin B blocked the activation of caspase-7, -8, and -1 but did not affect the activity of caspase-3, -9, and -2. Overall, these results suggest that TG-induced cytoplasmic cathepsin B causes THP-1 macrophage cell death by activating caspase-1, leading to subsequent activation of the extrinsic apoptotic pathway.
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참고문헌 (28)
참고문헌 신청
Ndrepepa G / 2017 / Atherosclerosis and ischaemic heart disease : Here to stay or gone tomorrow / Indian J Med Res 146:293~297
Hyungtae Kim / 2019 / Prevalence and incidence of atherosclerotic cardiovascular disease and its risk factors in Korea: a nationwide population-based study / BMC Public Health 19(1):1112
Moore KJ / 2013 / Macrophages in atherosclerosis : A dynamic balance / Nat Rev Immunol 13:709~721
Daniel J. Rader / 2005 / Lipoproteins, macrophage function, and atherosclerosis: Beyond the foam cell? / Cell Metabolism 1(4):223~230
I Tabas / 2004 / Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol / Cell Death & Differentiation 11(S1):S12~S16
Hyungtae Kim / 2019 / Prevalence and incidence of atherosclerotic cardiovascular disease and its risk factors in Korea: a nationwide population-based study / BMC Public Health 19(1):1112
Moore KJ / 2013 / Macrophages in atherosclerosis : A dynamic balance / Nat Rev Immunol 13:709~721
Daniel J. Rader / 2005 / Lipoproteins, macrophage function, and atherosclerosis: Beyond the foam cell? / Cell Metabolism 1(4):223~230
I Tabas / 2004 / Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol / Cell Death & Differentiation 11(S1):S12~S16
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