The Lung Function Impairment in Non-Atopic Patients With Chronic Rhinosinusitis and Its Correlation Analysis

Linghao Zhang; Lu Zhang; Chun-Hong Zhang; Xiao-Bi Fang; Zhen-Xiao Huang; Qing -Yuan Shi; Li-Ping Wu; Peng Wu; Zhen-Zhen Wang; Zhi-Su Liao

doi:http://dx.doi.org/10.21053/ceo.2015.01641

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자료유형: 학술저널

저자정보: Linghao Zhang (First Affiliated Hospital of Wenzhou Medical University) Lu Zhang (First Affiliated Hospital of Wenzhou Medical University) Chun-Hong Zhang (First Affiliated Hospital of Wenzhou Medical University) Xiao-Bi Fang (First Affiliated Hospital of Wenzhou Medical University) Zhen-Xiao Huang (Beijing Tongren Hospital) Qing -Yuan Shi (First Affiliated Hospital of Wenzhou Medical University) Li-Ping Wu (First Affiliated Hospital of Wenzhou Medical University) Peng Wu (First Affiliated Hospital of Wenzhou Medical University) Zhen-Zhen Wang (First Affiliated Hospital of Wenzhou Medical University) Zhi-Su Liao (First Affiliated Hospital of Wenzhou Medical University)

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제4호

발행연도: 2016.12

수록면: 339 - 345 (7page)

DOI: http://dx.doi.org/10.21053/ceo.2015.01641

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Objectives. Chronic rhinosinusitis (CRS) is common disease in otorhinolaryngology and will lead to lower airway abnormality. However, the only lung function in CRS patients and associated factors have not been much studied. Methods. One hundred patients with CRS with nasal polyps (CRSwNP group), 40 patients with CRS without nasal polyps (CRSsNP group), and 100 patients without CRS were enrolled. The difference in lung function was compared. Meanwhile, CRSwNP and CRSsNP group were required to undergo a bronchial provocation or dilation test. Additionally, subjective and objective outcomes were measured by the visual analogue scale (VAS), 20-item Sino-Nasal Outcome Test (SNOT-20), Lund-Mackay score, Lund-Kennedy endoscopic score. The correlation and regression methods were used to analyze the relationship between their lung function and the above parameters. Results. The forced expiratory volume in 1 second (FEV1) and forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75) of CRSwNP group were significantly lower than other groups (P<0.05). On peak expiratory flow, there was no difference between three groups. In CRSwNP group, FEV1 was negatively correlated with peripheral blood eosinophil count (PBEC) and duration of disease (r=?0.348, P=0.013 and r=?0.344, P=0.014, respectively), FEF25-75 negatively with VAS, SNOT-20 (r=?0.490, P=0.028 and r=?0.478, P=0.033, respectively) in CRSsNP group. The incidence of positive bronchial provocation and dilation test was lower in CRSwNP group (10% and 0%, respectively), with both 0% in CRSsNP group. The multiple linear regression analysis indicated that change ratio of FEV1 before and after bronchial provocation or dilation test were correlated with PBEC in CRSwNP group (β=0.403, P=0.006). Conclusion. CRS leading to impaired maximum ventilation and small airway is associated with the existence of nasal polyp. Lung function impairments can be reflected by PBEC, duration, VAS, and SNOT-20. In CRSwNP patients, PBEC is independent predictor of FEV1 change ratio.

#Chronic Rhinosinusitis #Lung Function #Bronchial Hyperreactivity #Bronchial Provocation Tests

참고문헌 (27)

참고문헌 신청

Rosenfeld RM. / 2007 / Clinical practice guideline: adult sinusitis / Otolaryngol Head Neck Surg 137(3 Suppl):S1~S31

Cherry DK. / 2002 / National Ambulatory Medical Care Survey: 2000 summary / Adv Data (328):1~32

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Bousquet J. / 2001 / Allergic rhinitis and its impact on asthma / J Allergy Clin Immunol 108(5 Suppl):S147~S334

Kim HY. / 2007 / Prevalence of lower airway diseases in patients with chronic rhinosinusitis / Acta Otoaryngol 127(Suppl 558):110~114

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