Local Allergic Inflammation in Chronic Rhinosinusitis With Nasal Polyps Could Influence on Disease Severity and Olfaction

Byung kee Youn; 김동규; Byung Hum Kim; Hyung Gu Kim; 정진혁; 조석현

doi:10.18787/jr.2021.00363

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저자정보: Byung kee Youn (Hanyang University College of Medicine) 김동규 (한림대학교) Byung Hum Kim (Hanyang University College of Medicine) Hyung Gu Kim (Hanyang University College of Medicine) 정진혁 (한양대학교) 조석현 (한양대학교)

저널정보: 대한비과학회 Journal of Rhinology Journal of Rhinology Vol.28 No.3

발행연도: 2021.11

수록면: 147 - 152 (6page)

DOI: 10.18787/jr.2021.00363

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Background and Objectives: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease resulting from inflammation of the nasal cavity and paranasal sinuses. Systemic allergic inflammation is an important cause of CRSwNP; however, the effect of local allergic inflammation is unclear. This study was designed to investigate the effect of local allergic inflammation in CRSwNP.Materials and Methods: The study included 11 patients with CRSwNP and 18 control subjects. Olfactory function was measured with the Korean Version of Sniffin’s stick test. Nasal lavage fluids (NLFs) were collected from all subjects and analyzed for total IgE, eosinophilic cationic protein (ECP), and cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-4, IL-10, IL-17A, interferon-γ). Flow cytometry was used to measure various inflammatory cells in the NAL fluids.Results: On analysis of flow cytometry and enzyme-linked immunosorbent assay, we found that CRSwNP patients had significantly increased eosinophil (%) and ECP levels in NLFs. In addition, there was significant local-systemic correlation between ECP level in NLFs and blood eosinophils (%) (r=0.391); however, there was no significant association between eosinophils (%) in NLFs and blood eosinophils. Moreover, in CRSwNP patients, the severity of disease was related with blood eosinophil (%), eosinophil (%), and ECP levels in NLFs, whereas olfactory function was associated with blood eosinophil (%) and ECP levels in NLFs.Conclusion: CRSwNP is a disease with high allergic inflammation that has negative impacts on the severity of disease and olfactory function. Therefore, we suggest that control of local allergic inflammation will be helpful to treat CRSwNP patients.

#Chronic rhinosinusitis #Polyp #Local #Immune

참고문헌 (26)

참고문헌 신청

Fokkens WJ / 2012 / EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists / Rhinology 50(1):1~12

Schleimer RP / 2017 / Immunopathogenesis of chronic rhinosinusitis and nasal polyposis / Annu Rev Pathol 12:331~357

Stevens WW / 2015 / Chronic rhinosinusitis pathogenesis / J Allergy Clin Immunol 136(6):1442~1453

Tomassen P / 2016 / Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers / J Allergy Clin Immunol 137(5):1449~1456

Bachert C / 1997 / IL-5 synthesis is upregulated in human nasal polyp tissue / J Allergy Clin Immunol 99(6):837~842

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