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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 175 - 181 (7page)
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초록· 키워드
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Tyrosol, a phenylethanoid and a derivative of phenethyl alcohol, possesses various biological properties, such as anti-oxidative and cardioprotective activity. Olive oil is the principal source of tyrosol in the human diet. However, so far the anti-cancer activity of tyrosol has not yet been well defined. This study therefore undertakes to examine the cytotoxic activity and the mechanism of cell death exhibited by tyrosol in KB human oral cancer cells. Treatment of KB cells with tyrosol induced the cell growth inhibition in a concentration- and a time-dependent manner. Furthermore, the treatment of tyrosol induced nuclear condensation and fragmentation of KB cells. Tyrosol also promoted proteolytic cleavage of procaspase-3, -7, -8 and ?9, increasing the amounts of cleaved caspase-3, -7, -8 and ?9. In addition, tyrosol increased the levels of cleaved PARP in KB cells.
These results suggest that tyrosol induces the suppression of cell growth and cell apoptosis in KB human oral cancer cells, and is therefore a potential candidate for anti-cancer drug discovery.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
J. W. Costerton / 1999 / Bacterial Biofilms: A Common Cause of Persistent Infections / Science 284(5418):1318~1322
R. C. V. Casarin / 2010 / Levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, inflammatory cytokines and species-specific immunoglobulin G in generalized aggressive and chronic periodontitis / Journal of Periodontal Research 45(5):635~642
Diya Zhang / 2008 / Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1β, TNF-α and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS / Innate Immunity 14(2):99~107
P. P. C. Souza / 2010 / Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2 / Journal of Dental Research 89(8):802~807
Julian M.W. Quinn / 2005 / Modulation of osteoclast formation / Biochemical and Biophysical Research Communications 328(3):739~745
R. C. V. Casarin / 2010 / Levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, inflammatory cytokines and species-specific immunoglobulin G in generalized aggressive and chronic periodontitis / Journal of Periodontal Research 45(5):635~642
Diya Zhang / 2008 / Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1β, TNF-α and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS / Innate Immunity 14(2):99~107
P. P. C. Souza / 2010 / Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2 / Journal of Dental Research 89(8):802~807
Julian M.W. Quinn / 2005 / Modulation of osteoclast formation / Biochemical and Biophysical Research Communications 328(3):739~745
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