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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 117 - 125 (9page)
- DOI
- http://dx.doi.org/10.11620/IJOB.2015.40.3.117
이용수
초록· 키워드
오류제보하기
The present study investigated the role of central GABAA and GABAB receptors in orofacial pain in rats. Experiments were conducted on Sprague-Dawley rats weighing between 230 and 280 g. Intracisternal catheterization was performed for intracisternal injection, under ketamine anesthesia.
Complete Freund's Adjuvant (CFA)-induced thermal hyperalgesia and inferior alveolar nerve injury-induced mechanical allodynia were employed as orofacial pain models. Intracisternal administration of bicuculline, a GABAA receptor antagonist, produced mechanical allodynia in naive rats, but not thermal hyperalgesia. However, CGP35348, a GABAB receptor antagonist, did not show any pain behavior in naive rats. Intracisternal administration of muscimol, a GABAA receptor agonist, attenuated the thermal hyperalgesia and mechanical allodynia in rats with CFA treatment and inferior alveolar nerve injury, respectively. On the contrary, intracisternal administration of bicuculline also attenuated the mechanical allodynia in rats with inferior alveolar nerve injury. Intracisternal administration of baclofen, a GABAB receptor agonist, attenuated the thermal hyperalgesia and mechanical allodynia in rats with CFA treatment and inferior alveolar nerve injury, respectively. In contrast to GABAA receptor antagonist, intracisternal administration of CGP35348 did not affect either the thermal hyperalgesia or mechanical allodynia. Our current findings suggest that the GABAA receptor, but not the GABAB receptor, participates in pain processing under normal conditions. Intracisternal administration of GABAA receptor antagonist, but not GABAB receptor antagonist, produces paradoxical antinociception under pain conditions. These results suggest that central GABA has differential roles in the processing of orofacial pain, and the blockade of GABAA receptor provides new therapeutic targets for the treatment of chronic pain.
목차
등록된 정보가 없습니다.
참고문헌 (56)
참고문헌 신청
Malcangio M / 1996 / GABA and its receptors in the spinal cord / Trends Pharmacol Sci 17:457~462
Sylvia Reichl / 2012 / Peripheral and spinal GABAergic regulation of incisional pain in rats / Pain 153(1):129~141
Carlton SM / 1990 / Light microscopic and ultrastructural analysis of GABA-immunoreactive profiles in the monkey spinal cord / J Comp Neurol 300:162~182
Antal M / 1996 / Direct evidence of an extensive GABAergic innervation of the spinal dorsal horn by fibres descending from the rostral ventromedial medulla / Neuroscience 73:509~518
Millhorn DE / 1987 / Immunohistochemical evidence for colocalization of gamma-aminobutyric acid and serotonin in neurons of the ventral medulla oblongata projecting to the spinal cord / Brain Res 410:179~185
Sylvia Reichl / 2012 / Peripheral and spinal GABAergic regulation of incisional pain in rats / Pain 153(1):129~141
Carlton SM / 1990 / Light microscopic and ultrastructural analysis of GABA-immunoreactive profiles in the monkey spinal cord / J Comp Neurol 300:162~182
Antal M / 1996 / Direct evidence of an extensive GABAergic innervation of the spinal dorsal horn by fibres descending from the rostral ventromedial medulla / Neuroscience 73:509~518
Millhorn DE / 1987 / Immunohistochemical evidence for colocalization of gamma-aminobutyric acid and serotonin in neurons of the ventral medulla oblongata projecting to the spinal cord / Brain Res 410:179~185
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