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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 978 - 984 (7page)
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초록· 키워드
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Osteoporosis is a disease that often occurs in postmenopausal women. The purpose of this study was to examine the positive effects of Cheongukjang powder containing menaquinone-7 (MK-7) on bone health circulation in postmenopausal women. Fifty-six postmenopausal women were recruited into a randomised double-blind placebo-controlled trial. The participants were randomly assigned into two groups. For 12 weeks, one group received 800 μg MK-7 in the form of Cheongukjang packs (CMK-7), and the other group received the same amount of identical-looking placebo packs containing barley meal for 12 weeks. Femoral bone mineral density (BMD), bone-specific alkaline phosphatase (ALP), deoxypyridinoline (DPD), osteocalcin (OSC), serum Ca, and serum P were measured at baseline (0 weeks) and 12 weeks. After 12 weeks in the CMK-7 group, it was found that BMD, serum Ca, and serum P had increased above the baseline (p<0.0001, p=0.0028, p<0.0001), whereas bone-specific ALP, DPD, and OSC had decreased below the baseline (p=0.0003, p<0.0001, p<0.0001). Therefore, MK-7 taken as Cheongukjang is expected to prevent osteoporosis in postmenopausal women.
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참고문헌 (27)
참고문헌 신청
Delmas PD / 1991 / Biochemical markers of bone turnover :methodology and clinical use in osteoporosis / Am J Med 91:59~63
Feinblatt J / 1970 / The effect of phosphate infusion on the bone metabolism and parathyroid hormone action / Am J Physical 218:1624~1631
Garmero P / 1996 / New developments in biochemical markers for osteoporosis / Calcif Tissue Int 59:2~9
Hara K / 1995 / The inhibitory effect of vitamin K2(menatetrenone)on bone resorption may be related to its side chain / Bone 16:179~184
Kaneki M / 2001 / Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2 : possible implications for hip-fracture risk / Nutrition 17:315~321
Feinblatt J / 1970 / The effect of phosphate infusion on the bone metabolism and parathyroid hormone action / Am J Physical 218:1624~1631
Garmero P / 1996 / New developments in biochemical markers for osteoporosis / Calcif Tissue Int 59:2~9
Hara K / 1995 / The inhibitory effect of vitamin K2(menatetrenone)on bone resorption may be related to its side chain / Bone 16:179~184
Kaneki M / 2001 / Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2 : possible implications for hip-fracture risk / Nutrition 17:315~321
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