지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 96 - 104 (9page)
이용수
초록· 키워드
오류제보하기
Background: The present experiment was conducted to identify the cooperative effect of serine histogranin (SHG) and noradrenaline in alleviating peripheral neuropathic pain.Methods: Chronic constriction injury of the right sciatic nerve was used to induce chronic neuropathic pain. For drug delivery, a PE10 tube was inserted into the subarachnoid space. Acetone drops and a 44oC water bath were used to evaluate the cold and heat allodynia, respectively. Placing and grasping reflexes were used to assess the locomotor system. Results: SHG at 0.5 and 1 μg significantly (P ＜ 0.05) decreased the thermal allodynia. The cold allodynia was also significantly reduced by intrathecal injections of 0.5 (P ＜ 0.05) and 1 μg (P ＜ 0.001) of SHG. 1 μg of noradrenaline, but not 0.5 μg, significantly alleviated the cold (P ＜ 0.01) and thermal (P ＜ 0.05) allodynia. The ameliorating effect of noradrenaline or SHG disappeared when the two compounds were administrated in equal concentrations. A significant difference (P ＜ 0.01 in the acetone and P ＜ 0.05 in the heat) was observed in the groups under equal doses of the two compounds, with a lower effectiveness of the combination therapy. Conclusions: Our findings suggest that the simultaneous administrations of noradrenaline and SHG do not result in synergistic analgesia, and combination therapy may not be a good approach to the treatment of chronic neuropathic pain syndrome. (Korean J Pain 2015; 28: 96-104)
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Alagarsamy S / 2005 / NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin / Neuropharmacology 49 (1) : 135 ~ 145
Amin B / 2012 / Antinociceptive evaluation of ceftriaxone and minocycline alone and in combination in a neuropathic pain model in rat / Neuroscience 224 : 15 ~ 25
Crosby G / 1990 / Subarachnoid clonidine reduces spinal cord blood flow and glucose utilization in conscious rats / Anesthesiology 73 : 1179 ~ 1185
D'Angelo R / 2013 / Neuropathic pain following spinal cord injury:what we know about mechanisms, assessment and management / Eur Rev Med Pharmacol Sci 17 : 3257 ~ 3261
Hahm TS / 2012 / Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain / Br J Anaesth 109 : 968 ~ 974
Amin B / 2012 / Antinociceptive evaluation of ceftriaxone and minocycline alone and in combination in a neuropathic pain model in rat / Neuroscience 224 : 15 ~ 25
Crosby G / 1990 / Subarachnoid clonidine reduces spinal cord blood flow and glucose utilization in conscious rats / Anesthesiology 73 : 1179 ~ 1185
D'Angelo R / 2013 / Neuropathic pain following spinal cord injury:what we know about mechanisms, assessment and management / Eur Rev Med Pharmacol Sci 17 : 3257 ~ 3261
Hahm TS / 2012 / Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain / Br J Anaesth 109 : 968 ~ 974
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Intravenous Administration of Substance P Attenuates Mechanical Allodynia Following Nerve Injury by Regulating Neuropathic Pain-Related Factors
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
신경병성통증의 중요성과 과제
대한의사협회지
2021 .01
-
신경병성통증의 평가와 진단
대한의사협회지
2021 .01
-
Effect of palmitoylethanolamide on inflammatory and neuropathic pain in rats
Korean Journal of Anesthesiology
2017 .01
-
Neuropathic Pain in Elderly Patients with Chronic Low Back Painand Effects of Pregabalin: A Preliminary Study
Asian Spine Journal
2015 .04
-
신경병성통증의 병태생리
대한의사협회지
2021 .01
-
An integrated review on new targets in the treatment of neuropathic pain
The Korean Journal of Physiology & Pharmacology
2019 .01
-
Investigation of serum biomarkers for neuropathic pain in neuromyelitis optica spectrum disorder: a preliminary study
Annals of Clinical Neurophysiology
2021 .01
-
Autophagy: Can It be a New Experimental Research Method of Neuropathic Pain?
The Korean Journal of Pain
2015 .01
-
Characterization of peripheral neuropathic pain model and the pain assessments for efficacy studies in rats
한국실험동물학회 학술발표대회 논문집
2023 .02
-
Spinal Gap Junction Channels in Neuropathic Pain
The Korean Journal of Pain
2015 .01
-
A 40-year-old man with neuropathic pain in the entire left foot
Journal of Yeungnam Medical Science
2023 .04
-
Neuropathic Pain after Adolescent Idiopathic Scoliosis Correction Surgery
Asian Spine Journal
2021 .10
-
The features of the neuropathic pain in patients with shoulder disorders
대한견주관절의학회 학술대회논문집
2015 .04
-
The Neuromodulation of Neuropathic Pain by Measuring Pain Response Rate and Pain Response Duration in Animal
대한신경외과학회지
2015 .01
-
Pain-relieved effect of Pregabalin in diabetic neuropathic pain model
한국실험동물학회 학술발표대회 논문집
2018 .01
-
The efficacy of GABAergic precursor cells transplantation in alleviating neuropathic pain in animal models: a systematic review and meta-analysis
The Korean Journal of Pain
2022 .01
-
Nicotine dependence and the International Association for the Study of Pain neuropathic pain grade in patients with chronic low back pain and radicular pain: is there an association?
The Korean Journal of Pain
2020 .01
-
Comparison of Neuropathic Pain in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis
Journal of Clinical Neurology
2020 .01
-
The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain
The Korean Journal of Physiology & Pharmacology
2017 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0