지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제5호
- 발행연도
- 2018.9
- 수록면
- 525 - 538 (14page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.5.525
이용수
초록· 키워드
오류제보하기
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported pharmacological properties of tetramethylpyrazine (TMP) include anti-cancer, anti-diabetic, anti-atherosclerotic, and neuropsychiatric activities. However, the anxiolytic-like effects of TMP and its mechanism of action in PTSD are unclear. This study measured several anxiety-related behavioral responses to examine the effects of TMP on symptoms of anxiety in rats after single prolonged stress (SPS) exposure by reversing the serotonin (5-HT) and hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Rats were given TMP (10, 20, or 40 mg/kg, i.p.) for 14 days after SPS exposure. Administration of TMP significantly reduced grooming behavior, increased the time spent and number of visits to the open arm in the elevated plus maze test, and significantly increased the number of central zone crossings in the open field test. TMP administration significantly reduced the freezing response to contextual fear conditioning and significantly restored the neurochemical abnormalities and the SPS-induced decrease in 5-HT tissue levels in the prefrontal cortex and hippocampus. The increased 5-HT concentration during TMP treatment might be partially attribute to the tryptophan and 5-hydroxyindoleacetic acid mRNA level expression in the hippocampus of rats with PTSD. These findings support a role for reducing the altered serotonergic transmission in rats with PTSD. TMP simultaneously attenuated the HPA axis dysfunction.
Therefore, TMP may be useful for developing an agent for treating psychiatric disorders, such those observed in patients with PTSD.
목차
등록된 정보가 없습니다.
참고문헌 (68)
참고문헌 신청
Enman NM / 2015 / Anhedonia, reduced cocaine reward, and dopamine dysfunction in a rat model of posttraumatic stress disorder / Biol Psychiatry 78:871~879
Wilson CB / 2014 / Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder / Behav Brain Res 268:72~80
Ji LL / 2014 / Intra-hippocampal administration of ZIP alleviates depressive and anxietylike responses in an animal model of posttraumatic stress disorder / Behav Brain Funct 10:28
Rau V / 2005 / Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder / Neurosci Biobehav Rev 29:1207~1223
Shin LM / 2010 / The neurocircuitry of fear, stress, and anxiety disorders / Neuropsychopharmacology 35:169~191
Wilson CB / 2014 / Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder / Behav Brain Res 268:72~80
Ji LL / 2014 / Intra-hippocampal administration of ZIP alleviates depressive and anxietylike responses in an animal model of posttraumatic stress disorder / Behav Brain Funct 10:28
Rau V / 2005 / Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder / Neurosci Biobehav Rev 29:1207~1223
Shin LM / 2010 / The neurocircuitry of fear, stress, and anxiety disorders / Neuropsychopharmacology 35:169~191
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