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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제19권 제5호
- 발행연도
- 2015.9
- 수록면
- 413 - 420 (8page)
이용수
초록· 키워드
오류제보하기
Dexmedetomidine is a sedative and analgesic agent that exerts its effects by selectively agonizing α2 adrenoceptor. Histamine is a pathophysiological amine that activates G protein-coupled receptors, to induce Ca2+ release and subsequent mediate or progress inflammation. Dexmedetomidine has been reported to exert inhibitory effect on inflammation both in vitro and in vivo studies. However, it is unclear that dexmedetomidine modulates histamine-induced signaling and pro-inflammatory cytokine expression. This study was carried out to assess how dexmedetomidine modulates histamine-induced Ca2+ signaling and regulates the expression of pro-inflammatory cytokine genes encoding interleukin (IL)-6 and -8. To elucidate the regulatory role of dexmedetomidine on histamine signaling, HeLa cells and human salivary gland cells which are endogenously expressed histamine 1 receptor were used.
Dexmedetomidine itself did not trigger Ca2+ peak or increase in the presence or absence of external Ca2+. When cells were stimulated with histamine after pretreatment with various concentrations of dexmedetomidine, we observed inhibited histamine-induced [Ca2+]i signal in both cell types. Histamine stimulated IL-6 mRNA expression not IL-8 mRNA within 2 hrs, however this effect was attenuated by dexmedetomidine. Collectively, these findings suggest that dexmedetomidine modulates histamine-induced Ca2+ signaling and IL-6 expression and will be useful for understanding the antagonistic properties of dexmedetomidine on histamine-induced signaling beyond its sedative effect.
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참고문헌 (44)
참고문헌 신청
Kamibayashi T / 2000 / Clinical uses of alpha2 -adrenergic agonists / Anesthesiology 93:1345~1349
Jackson KC 3rd / 2006 / Dexmedetomidine: a novel analgesic with palliative medicine potential / J Pain Palliat Care Pharmacother 20:23~27
Kocoglu H / 2008 / Preconditionin effects of dexmedetomidine on myocardial ischemia/reperfusion injury in rats / Curr Ther Res Clin Exp 69:150~158
Hoffman WE / 1991 / Reversal by the alpha 2-adrenergic antagonist atipamezole / Anesthesiology 75:328~332
Okada H / 2007 / The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts / Resuscitation 74:538~545
Jackson KC 3rd / 2006 / Dexmedetomidine: a novel analgesic with palliative medicine potential / J Pain Palliat Care Pharmacother 20:23~27
Kocoglu H / 2008 / Preconditionin effects of dexmedetomidine on myocardial ischemia/reperfusion injury in rats / Curr Ther Res Clin Exp 69:150~158
Hoffman WE / 1991 / Reversal by the alpha 2-adrenergic antagonist atipamezole / Anesthesiology 75:328~332
Okada H / 2007 / The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts / Resuscitation 74:538~545
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