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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.3
- 수록면
- 38 - 42 (5page)
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초록· 키워드
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Objectives: In this study, the destabilizing effect of glycyrrhetinic acid on pre-formed biofilms of Streptococcus mutans ( S. mutans ) was observed. Methods: Alamar blue assay was used to determine the toxicity of glycyrrhetinic acid on pre-formed biofilms of S. mutans . Four different concentrations (0, 3.75, 7.5, 15 ?g/ml) of glycyrrhetinic acid were tested. Changes in the biofilm architecture after exposure to glycyrrhetinic acid were analyzed by scanning electron microscopy (SEM). Moreover, the role of glycyrrhetinic acid in enhancing the antimicrobial activity of cetylpyridinium chloride (CPC), an antimicrobial agent commonly used in oral health care products, was evaluated. Results: Glycyrrhetinic acid concentration of up to 15 ?g/ml had little cytotoxic effect but significantly changed the biofilm architecture. SEM analysis revealed destabilized biofilm structure after the preformed biofilms were exposed to glycyrrhetinic acid. Supplementing 2.5 ?g/ml CPC with 15 ?g/ml glycyrrhetinic acid significantly enhanced the bactericidal effect of CPC on the pre-formed biofilms than that in the non-supplemented CPC treated control. This indicates that glycyrrhetinic acid enhanced the antimicrobial activity of CPC by modifying the structure, thus facilitating the penetration of CPC into the biofilm. Conclusions: Glycyrrhetinic acid could be a potential agent to effectively control S. mutans biofilms responsible for dental caries.
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참고문헌 (17)
참고문헌 신청
Liu Y / 2011 / Effect of the antimicrobial decapeptide KSL on the growth of oral pathogens and Streptococcus mutans biofilm / Int J Antimicrob Agents 37:33~38
Yoshida A / 2005 / LuxS-based signaling affects Streptococcus mutans biofilm formation / Appl Environ Microbol 71:2372~2380
Costerton JW / 1999 / Bacterial biofilms: A common cause of persistent infections / Science 60:756~762
Zhiyan H / 2012 / Use of the quorum sensing inhibitor furanone C-30 to interfere with biofilm formation by Streptococcus mutans and its luxS mutant strain / Int J Antimicrob Agents 40:30~35
Eley BM / 1999 / Antibacterial agents in the control of supragingival plaque-a review / Br Dent J 186:286~296
Yoshida A / 2005 / LuxS-based signaling affects Streptococcus mutans biofilm formation / Appl Environ Microbol 71:2372~2380
Costerton JW / 1999 / Bacterial biofilms: A common cause of persistent infections / Science 60:756~762
Zhiyan H / 2012 / Use of the quorum sensing inhibitor furanone C-30 to interfere with biofilm formation by Streptococcus mutans and its luxS mutant strain / Int J Antimicrob Agents 40:30~35
Eley BM / 1999 / Antibacterial agents in the control of supragingival plaque-a review / Br Dent J 186:286~296
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