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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제38권 제2호
- 발행연도
- 2016.2
- 수록면
- 1 - 5 (5page)
- DOI
- 10.1186/s40902-016-0053-5
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초록· 키워드
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Background: This study examined the osteoinductive activity of demineralized dentin matrix (DDM) from humanand polydeoxyribonucleotide (PDRN) for nude mice.
Methods: Twenty healthy nude mice, weighing about 15~20 g, were used for the study. DDM from human andPDRN were prepared and implanted subcutaneously into the dorsal portion of the nude mice. The nude mice weresacrificed at 1, 2, and 4 weeks after grafting and evaluated histologically by hematoxylin-eosin and Masson’strichrome staining. The specimens were also evaluated via a histomorphometric study.
Results: The DDM and PDRN induced new bone, osteoblasts, and fibroblasts in soft tissues. The histological findingsshowed bone-forming cells like osteoblasts and fibroblasts at 1, 2, and 4 weeks. New bone formation was observed inthe histomorphometric study. In particular, the ratio of new bone formation was the highest at 2 weeks comparedwith the first week and fourth week.
Conclusions: In this study, we showed that the PDRN used in this experimental model was able to induce boneregeneration when combined to the DDM.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Rubegni P / 2001 / Clinical evaluation of the trophic effect of polydeoxyribonucleotide (PDRN) in patients undergoing skin explants. A pilot study / Curr Med Res Opin 17:128~131
김경욱 / 2011 / 자가치아골이식재의 결정구조 분석: X선 회절 분석 / 대한구강악안면외과학회지 37(3):225~228
Kim YK / 2010 / Development of a novel bone grafting material using autogenous teeth / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:496~503
Galeano M / 2008 / Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse / Wound Repair Regen 16:208~217
Bitto A / 2008 / Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury / Crit Care Med 36:1594~1602
김경욱 / 2011 / 자가치아골이식재의 결정구조 분석: X선 회절 분석 / 대한구강악안면외과학회지 37(3):225~228
Kim YK / 2010 / Development of a novel bone grafting material using autogenous teeth / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:496~503
Galeano M / 2008 / Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse / Wound Repair Regen 16:208~217
Bitto A / 2008 / Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury / Crit Care Med 36:1594~1602
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