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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 230 - 230 (1page)
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Background: This study was conducted to investigate the synergic effects of polydeoxyribonucleotide (PDRN) combined with microcurrent therapy (MT) on an atrophied calf muscle in a cast-immobilized rabbit model.
Methods: Thirty-two male New Zealand rabbits at 12 weeks of age were allocated into 4 groups. After 2 weeks cast-immobilization, 4 types of procedures [normal saline 0.2ml injection group 1 (G1-NS); 0.2ml PDRN injection group 2 (G2-PDRN); MT group 3 (G3-MT); and 0.2ml PDRN injection with MT group 4 (G4-PDRN+MT)] were performed at atrophied calf muscle. MT (alternating current, 200μA, 30 Hz, rectangular pulse) was applied 60 minutes daily for 4 weeks. Calf Circumference (CC), Compound Muscle Action Potential (CMAP) of tibial nerve, and Thickness of Gastrocnemius muscle (TGCM) using ultrasound were evaluated before and after 4 weeks of treatment. Cross Sectional Area (CSA) of GCM fibers (type I, II and total), Proliferating Cell Nuclear Antigen (PCNA), vascular endothelial growth factor, and Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) were measured.
Results: G4-PDRN+MT (18.3±1.3, 20.0±1.6, 14.3±0.5/14.1±0.6) showed significantly lower in the mean atrophic changes of right CC, CMAP, TGCM (medial/lateral) than those in the G1-NS (23.0±1.6, 23.2±1.7, 16.3±0.8/15.9±0.6), G2-PDRN (19.3±1.4, 21.9±1.7, 14.8±0.9/14.6±0.7) and G3-MT (19.9±1.5, 21.5±1.8, 15.1±0.1/14.8±0.6), respectively (P < 0.05). In addition, the mean CSAs (type I, II ... 전체 초록 보기
Methods: Thirty-two male New Zealand rabbits at 12 weeks of age were allocated into 4 groups. After 2 weeks cast-immobilization, 4 types of procedures [normal saline 0.2ml injection group 1 (G1-NS); 0.2ml PDRN injection group 2 (G2-PDRN); MT group 3 (G3-MT); and 0.2ml PDRN injection with MT group 4 (G4-PDRN+MT)] were performed at atrophied calf muscle. MT (alternating current, 200μA, 30 Hz, rectangular pulse) was applied 60 minutes daily for 4 weeks. Calf Circumference (CC), Compound Muscle Action Potential (CMAP) of tibial nerve, and Thickness of Gastrocnemius muscle (TGCM) using ultrasound were evaluated before and after 4 weeks of treatment. Cross Sectional Area (CSA) of GCM fibers (type I, II and total), Proliferating Cell Nuclear Antigen (PCNA), vascular endothelial growth factor, and Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) were measured.
Results: G4-PDRN+MT (18.3±1.3, 20.0±1.6, 14.3±0.5/14.1±0.6) showed significantly lower in the mean atrophic changes of right CC, CMAP, TGCM (medial/lateral) than those in the G1-NS (23.0±1.6, 23.2±1.7, 16.3±0.8/15.9±0.6), G2-PDRN (19.3±1.4, 21.9±1.7, 14.8±0.9/14.6±0.7) and G3-MT (19.9±1.5, 21.5±1.8, 15.1±0.1/14.8±0.6), respectively (P < 0.05). In addition, the mean CSAs (type I, II ... 전체 초록 보기
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