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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제46권 제7호
- 발행연도
- 2016.12
- 수록면
- 669 - 675 (7page)
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초록· 키워드
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Fucoxanthin-loaded oil-in-water emulsions (FLEs) were prepared using medium chain triglyceride as an oil phase and L-a-phosphatidylcholine as an emulsifier. The stability of FLEs stored under dark condition at 25 C was investigated for 15 days in terms of droplet size change and fucoxanthin deterioration. The size of oil droplets on optical microscopic photos was about 3 lm immediately after preparation. And it increased to about 16 lm 15 days after preparation. The fucoxanthin content in FLEs was almost 90 % of its initial content soon after preparation, and it decreased to 75 % 15 days after preparation. The in vivo antiobesity efficacy of FLEs was investigated by applying the emulsion daily on the back of rat for 30 days and measuring the body weight, the liver weight and the leptin concentration in the blood of the rats. FLEs?treated rats showed lower body weight and liver weight 30 days after the application than FLEs?untreated rats did. And the leptin concentration in the blood markedly decreased upon the application of FLEs.
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참고문헌 (17)
참고문헌 신청
Bagwe RP. / 2001 / Improved drug delivery using microemulsions : rationale, recent progress, and new horizons / Crit Rev Ther Drug Carr Syst 18:77~140
Jing Dai / 2014 / Preparation and stability of fucoxanthin-loaded microemulsions / Journal of Industrial and Engineering Chemistry 20(4):2103~2110
Gundermann K. / 2012 / Factors determining the fluorescence yield of fucoxanthin-chlorophyll complexes(FCP)involved in non-photochemical quenching in diatoms / Biochim Biophys Acta Bioenerg 1817:1044~1052
Kajikawa T. / 2012 / Stereocontrolled total synthesis of fucoxanthin and its polyene chain-modified derivative / Org Lett 14:808~811
Kotake-Nara E. / 2005 / Neoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells / Cancer Lett 220:75~84
Jing Dai / 2014 / Preparation and stability of fucoxanthin-loaded microemulsions / Journal of Industrial and Engineering Chemistry 20(4):2103~2110
Gundermann K. / 2012 / Factors determining the fluorescence yield of fucoxanthin-chlorophyll complexes(FCP)involved in non-photochemical quenching in diatoms / Biochim Biophys Acta Bioenerg 1817:1044~1052
Kajikawa T. / 2012 / Stereocontrolled total synthesis of fucoxanthin and its polyene chain-modified derivative / Org Lett 14:808~811
Kotake-Nara E. / 2005 / Neoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells / Cancer Lett 220:75~84
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