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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제46권 제2호
- 발행연도
- 2016.4
- 수록면
- 169 - 178 (10page)
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초록· 키워드
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The ethanol extract of Phyllanthus amarus (Schum and Thonn), a plant of ethnomedicinal importance, was formulated into herbal cream and ointment and evaluated using physicochemical, safety and antimicrobial properties. The extract was obtained by maceration and the antimicrobial properties tested on clinically isolated pathogenic bacteria (Staphylococcus aureus and Pseudomonas aeruginosa) and dermatophytes (Trichophyton rubrum and Candida albicans) using established methods.
Cream and ointment formulations containing 1?10 % w/w extract was prepared and 4 % w/w humectant (glycerin) was incorporated into the cream while 5 % w/w surfactant (cetomacrogol 1000) was incorporated to the ointment. The results showed that the pH of the formulations was acidic and the viscosity ranged from 1250 to 4950 cP for ointments and 570?1233 cP for creams. The presence of humectant and surfactant significantly (p\0.05) reduced the viscosities of the formulations. The results of dermal irritation showed negligible irritation index while subchronic toxicity tests showed that the formulations did not cause any visible lesions in the skin of the animals after application for twenty-one days. The in vitro antimicrobial properties of formulations were concentration-dependent with the creams showing higher activity. Furthermore, the in vivo activity of the cream on S. aureus showed increased antibacterial activity with increase in extract concentration and humectant presence. The herbal cream and ointment of Phyllanthus amarus extract had acceptable physicochemical and safety profiles with significant (p\0.05) in vitro and in vivo antimicrobial activity. Thus, the formulations could be useful in the treatment of skin infections instead of using the extract for bathing and rubbing.
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참고문헌 (30)
참고문헌 신청
Adegoke AA. / 2010 / Studies on phytochemical screening and antimicrobial potentials of Phyllanthus amarus against multiple antibiotic resistant bacteria / Int J Appl Res Nat Prod 3(3):6~12
Adeyeye MC. / 2002 / Viscoelastic evaluation of topical creams containing microcytalline cellulose/sodium carboxymethyl cellulose as stablizer / AAPS Pharm Sci Tech 3(2):16~25
Ajala TO. / 2011 / The antiplasmodial effect of the extracts and formulated capsules of Phyllanthus amarus on Plasmodium yoelii infection in mice / Asian Pac J Trop Med 4(4):283~287
Akinjogunla OJ. / 2010 / Antibacterial activity of ethanolic extracts of Phyllanthus amarus against extended spectrum–lactamase producing Escherichia coli isolated from stool samples of HIV sero positive patients with or without diarrhea / Afr J Pharm Pharmacol 4(6):402~407
Ansel C. / 2005 / Disperse systems. In: Pharmaceutical dosage forms and drug delivery systems / Lippincott Williams and Wilkins :387~398
Adeyeye MC. / 2002 / Viscoelastic evaluation of topical creams containing microcytalline cellulose/sodium carboxymethyl cellulose as stablizer / AAPS Pharm Sci Tech 3(2):16~25
Ajala TO. / 2011 / The antiplasmodial effect of the extracts and formulated capsules of Phyllanthus amarus on Plasmodium yoelii infection in mice / Asian Pac J Trop Med 4(4):283~287
Akinjogunla OJ. / 2010 / Antibacterial activity of ethanolic extracts of Phyllanthus amarus against extended spectrum–lactamase producing Escherichia coli isolated from stool samples of HIV sero positive patients with or without diarrhea / Afr J Pharm Pharmacol 4(6):402~407
Ansel C. / 2005 / Disperse systems. In: Pharmaceutical dosage forms and drug delivery systems / Lippincott Williams and Wilkins :387~398
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