Safety, Efficacy, and Physicochemical Characterization of Tinospora crispa Ointment : A Community-Based Formulation against Pediculus humanus capitis :A Community-Based Formulation against Pediculus humanus capitis

Gerwin Louis Tapan Dela Torre; Kerstin Mariae Gonzales Ponsaran; Angelica Louise Dela Peña de Guzman; Richelle Ann Mallapre Manalo; Erna Custodio Arollado

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자료유형: 학술저널

저자정보: Gerwin Louis Tapan Dela Torre (University of the Philippines Manila) Kerstin Mariae Gonzales Ponsaran (University of the Philippines Manila) Angelica Louise Dela Peña de Guzman (University of the Philippines Manila) Richelle Ann Mallapre Manalo (University of the Philippines Manila) Erna Custodio Arollado (University of the Philippines Manila)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.55 No.4

발행연도: 2017.8

수록면: 409 - 416 (8page)

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The high prevalence of pediculosis capitis, commonly known as head lice (Pediculus humanus capitis) infestation, has led to the preparation of a community-based pediculicidal ointment, which is made of common household items and the extract of Tinospora crispa stem. The present study aimed to evaluate the safety, efficacy, and physicochemical characteristics of the T. crispa pediculicidal ointment. The physicochemical properties of the ointment were characterized, and safety was determined using acute dermal irritation test (OECD 404), while the efficacy was assessed using an in vitro pediculicidal assay. Furthermore, the chemical compounds present in T. crispa were identified using liquid-liquid extraction followed by ultra-performance liquid chromatography quadruple time-of-flight mass spectrometric (UPLC-qTOF/MS) analysis. The community-based ointment formulation was light yellow in color, homogeneous, smooth, with distinct aromatic odor and pH of 6.92±0.09. It has spreadability value of 15.04±0.98 g·cm/sec and has thixotropic behavior. It was also found to be non-irritant, with a primary irritation index value of 0.15. Moreover, it was comparable to the pediculicidal activity of the positive control Kwell<SUP>®</SUP>, a commercially available 1% permethrin shampoo (P>0.05), and was significantly different to the activity of the negative control ointment, a mixture of palm oil and candle wax (P<0.05). These findings suggested that the community-based T. crispa pediculicidal ointment is safe and effective, having acceptable physicochemical characteristics. Its activity can be attributed to the presence of compounds moupinamide and physalin I.

#Pediculus humanus capitis #Tinospora crispa #dermal irritation #ointment #pediculicidal assay

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