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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 733 - 739 (7page)
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초록· 키워드
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Background: Seborrheic dermatitis (SD) is a multifactorial disease; Malassezia species play an important role in its pathogenesis. Objective: We aimed to determine whether a cream containing climbazole/piroctone olamine (C/P cream), antifungal agents with expected efficacy against Malassezia species, could improve SD symptoms. Methods: We instructed 24 patients with mild-to-moderate SD to apply the C/P cream and emollient cream on the right and left sides of the face, respectively, every morning and evening for 4 weeks. The casual sebum level (measured with SebumeterⓇ; Courage & Khazaka Electronic GmbH, Germany) and the extent of erythema (measured with MexameterⓇ; Courage & Khazaka Electronic GmbH) on the face were measured at baseline and after 4 weeks. The minimal inhibitory concentration (MIC) was determined to demonstrate the antifungal activity of the C/P cream. Results: The casual sebum level and erythema were measured at week 4, and the median values demonstrated a quantitative improvement on the C/P cream-treated right side of the face compared to the emollient cream-treated left side. For the C/P cream, the MICs were 0.625, 5, 0.625, and 2.5 mg/ml for Malassezia restricta, M. globosa, M. sympodialis , and M. slooffiae, respectively.
Conclusion: Based on the reduced casual sebum level and extent of erythema, the antifungal activity of C/P cream against Malassezia species seems useful for the treatment of mild to moderate SD.
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참고문헌 (32)
참고문헌 신청
Gupta AK. / 2004 / Seborrheic dermatitis / J Eur Acad Dermatol Venereol 18:13~26
Elewski BE / 2009 / Safe and effective treatment of seborrheic dermatitis / Cutis 83:333~338
Gupta AK. / 2003 / Seborrheic dermatitis / Dermatol Clin 21:401~412
Alizadeh N. / 2014 / Comparison the efficacy of fluconazole and terbinafine in patients with moderate to severe seborrheic dermatitis / Dermatol Res Pract 2014:705402
Kastarinen H. / 2015 / Topical anti-inflammatory agents for seborrheic dermatitis of the face or scalp : summary of a Cochrane Review / JAMA Dermatol 151:221~222
Elewski BE / 2009 / Safe and effective treatment of seborrheic dermatitis / Cutis 83:333~338
Gupta AK. / 2003 / Seborrheic dermatitis / Dermatol Clin 21:401~412
Alizadeh N. / 2014 / Comparison the efficacy of fluconazole and terbinafine in patients with moderate to severe seborrheic dermatitis / Dermatol Res Pract 2014:705402
Kastarinen H. / 2015 / Topical anti-inflammatory agents for seborrheic dermatitis of the face or scalp : summary of a Cochrane Review / JAMA Dermatol 151:221~222
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