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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제45권 제1호
- 발행연도
- 2015.2
- 수록면
- 23 - 33 (11page)
이용수
초록· 키워드
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The purpose of this research work was todesign and develop droplet solidification apparatus for lipidbased pastilles. Oral lipid based multiparticulate pastillesof solid lipid glycerol monostearate were formulated tocontrol the release of highly water soluble drug metoprololsuccinate. The apparatus was optimized at 14G needle sizeand metallic surface base plate cooled at 4 ˚C. Pastilleswere evaluated for their size, shape, contact angle, density,flow properties, friability, crushing strength, drug content,thermal properties, in vitro and in vivo drug release. Pastilleswere hemispherical in shape of size 3.1?4.3 mm.
Contact angle was found to be more than 120˚. Drugrelease was controlled for 8 h. Scanning electron microscopystudy revealed the smooth external surface with poresto ingress dissolution media to enhance the drug releaserate. Increased quantity of pore former enhanced the dissolutionrate. Other operating variables like contact angleand height of needle from base plate were found to affectthe size of pastilles. The dissolution of optimized batch ofpastilles was best fitted to first order kinetic model. In vivopharmacokinetic study showed correlation with in vitrodrug release profile.
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참고문헌 (31)
참고문헌 신청
Abdul S / 2010 / A flexible technology for modified-release drugs: multiple-unit pellet system, (MUPS) / J Controlled Release 147:2~16
Almeida PS / 2005 / Starch–dextrin mixtures as base excipients for extrusion–spheronization pellets / Eur J Pharm Biopharm 59:511~521
Almeida A / 2011 / Ethylene vinyl acetate as matrix for oral sustained release dosage forms produced via hot-melt extrusion / Eur J Pharm Biopharm 77:297~305
Cespi M / 2007 / Stress relaxation test for the characterization of the viscoelasticity of pellets / Eur J Pharm Biopharm 67:476~484
Chakraborty S / 2009 / Lipid-an emerging platform for oral delivery of drugs with poor bioavailability / Eur J Pharm Biopharm 73:1~15
Almeida PS / 2005 / Starch–dextrin mixtures as base excipients for extrusion–spheronization pellets / Eur J Pharm Biopharm 59:511~521
Almeida A / 2011 / Ethylene vinyl acetate as matrix for oral sustained release dosage forms produced via hot-melt extrusion / Eur J Pharm Biopharm 77:297~305
Cespi M / 2007 / Stress relaxation test for the characterization of the viscoelasticity of pellets / Eur J Pharm Biopharm 67:476~484
Chakraborty S / 2009 / Lipid-an emerging platform for oral delivery of drugs with poor bioavailability / Eur J Pharm Biopharm 73:1~15
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