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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Jeong Tae (College of Pharmacy, Graduate School of Pharmaceutical Management, Chung-Ang University) Barua, Sonia (College of Pharmacy, Graduate School of Pharmaceutical Management, Chung-Ang University) Kim, Hyeongmin (College of Pharmacy, Graduate School of Pharmaceutical Management, Chung-Ang University) Hong, Seong-Chul (College of Pharmacy, Graduate School of Pharmaceutical Management, Chung-Ang University) Yoo, Seung-Yup (College of Pharmacy, Graduate School of Pharmaceutical Management, Chung-Ang University) Jeon, Hyojin (College of Pharmacy, Graduate School of Pharmaceutical Management, Chung-Ang University) Cho, Yeongjin (Department of Pharmaceutical Industry, Graduate School of Pharmaceutical Management, Chung-Ang University) Gil, Sangwon (Department of Pharmaceutical Industry, Graduate School of Pharmaceutical Management, Chung-Ang University) Oh, Kyungsoo (College of Pharmacy, Graduate School of Pharmaceutical Management, Chung-Ang University) Lee, Jaehwi (College of Pharmacy, Graduate School of Pharmaceutical Management, Chung-Ang University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제25권 제4호
발행연도
2017.1
수록면
452 - 459 (8page)

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In this study, the effect of particle size of genistein-loaded solid lipid particulate systems on drug dissolution behavior and oral bioavailability was investigated. Genistein-loaded solid lipid microparticles and nanoparticles were prepared with glyceryl palmitostearate. Except for the particle size, other properties of genistein-loaded solid lipid microparticles and nanoparticles such as particle composition and drug loading efficiency and amount were similarly controlled to mainly evaluate the effect of different particle sizes of the solid lipid particulate systems on drug dissolution behavior and oral bioavailability. The results showed that genistein-loaded solid lipid microparticles and nanoparticles exhibited a considerably increased drug dissolution rate compared to that of genistein bulk powder and suspension. The microparticles gradually released genistein as a function of time while the nanoparticles exhibited a biphasic drug release pattern, showing an initial burst drug release, followed by a sustained release. The oral bioavailability of genistein loaded in solid lipid microparticles and nanoparticles in rats was also significantly enhanced compared to that in bulk powders and the suspension. However, the bioavailability from the microparticles increased more than that from the nanoparticles mainly because the rapid drug dissolution rate and rapid absorption of genistein because of the large surface area of the genistein-solid lipid nanoparticles cleared the drug to a greater extent than the genistein-solid lipid microparticles did. Therefore, the findings of this study suggest that controlling the particle size of solid-lipid particulate systems at a micro-scale would be a promising strategy to increase the oral bioavailability of genistein.
#Genistein #Solid lipid particles #Particle size #Oral bioavailability #Dissolution behavior #Glyceryl palmitostearate

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참고문헌 (29)

참고문헌 신청
Boyd, B. J. / 2007 / A lipid-based liquid crystalline matrix that provides sustained release and enhanced oral bioavailability for a model poorly water soluble drug in rats / Int. J. Pharm 340:52~60 google schola Desai, J. / 2016 / Effect of particle size on oral bioavailability of darunavir-loaded solid lipid nanoparticles / J. Microencapsul 33:669~678 google schola Dingler, A. / 2002 / Production of solid lipid nanoparticles (SLN): scaling up feasibilities / J. Microencapsul 19:11~16 google schola Dixon, R. A. / 2002 / Genistein / Phytochemistry 60:205~211 google schola Drover, D. R. / 2002 / Input characteristics and bioavailability after administration of immediate and a new extendedrelease formulation of hydromorphone in healthy volunteers / Anesthesiology 97:827~836 google schola

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