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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 756 - 761 (6page)
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We have identified 88 interactor candidates for human growth hormone (GH) by the yeast two-hybrid assay. Among those, we focused our efforts on carboxypeptidase E (CPE), which has been thought to play a key role in sorting prohormones, such as pro-opiomelanocortin (POMC), to regulated secretory vesicles. We found that CPE co-localizes with and interacts with GH in AtT20 pituitary cells. Downregulation of CPE led to decreased levels of GH secretion, consistent with involvement of CPE in GH sorting/secretion. Our binding assay in vitro with bacterially expressed proteins suggested that GH directly interacts with CPE but in a manner different from POMC.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Ballinger, A. / 2001 / Growth failure and intestinal inflammation / Qjm 94:121~125
Burgess, T. L. / 1987 / Constitutive and regulated secretion of proteins / Annu. Rev. Cell Biol 3:243~293
Cawley, N. X. / 2003 / Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat)mice / Endocrinology 144:292~298
Cawley, N. X. / 2012 / New roles of carboxypeptidase E in endocrine and neural function and cancer / Endocr. Rev 33:216~253
Cool, D. R. / 1998 / Carboxypeptidase E is a sorting receptor for prohormones : binding and kinetic studies / Mol. Cell. Endocrinol 139:7~13
Burgess, T. L. / 1987 / Constitutive and regulated secretion of proteins / Annu. Rev. Cell Biol 3:243~293
Cawley, N. X. / 2003 / Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat)mice / Endocrinology 144:292~298
Cawley, N. X. / 2012 / New roles of carboxypeptidase E in endocrine and neural function and cancer / Endocr. Rev 33:216~253
Cool, D. R. / 1998 / Carboxypeptidase E is a sorting receptor for prohormones : binding and kinetic studies / Mol. Cell. Endocrinol 139:7~13
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