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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 281 - 285 (5page)
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초록· 키워드
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Almost all of eukaryotic mRNAs are subjected to polyad-enylation during mRNA processing. Recent discoveries showed that many of these mRNAs contain more than one polyadenylation sites in their 3’ untranslated regions (UTR) and that alternative polyadenylation (APA) is prevalent among these genes. Many biological processes such as differentiation, proliferation, and tumorigenesis have been correlated to global APA events in the 3’ UTR of mRNAs, suggesting that these APA events are tightly regulated and may play important physiological roles. In this review, recent discoveries in the physiological roles of APA events, as well as the known and proposed mechanisms are summarized. Perspective for future directions is also discussed.
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참고문헌 (42)
참고문헌 신청
Barabino, S. M. L. / 1999 / Last but not least : fegulated Poly(A)tail formation / Cell 99:9~11
Bava, F. / 2013 / CPEB1 coordinates alternative 3prime]-UTR formation with translational regulation / Nature 495:121~125
Beaudoing, E. / 2000 / Patterns of variant polyadenylation signal usage in human genes / Genome Res 10:1001~1010
Beisang, D. / 2014 / Alternative polyadenylation regulates CELF1/CUGBP1 target transcripts following T cell activation / Gene 550:93~100
Boutet, S. / 2012 / Alternative polyadenylation mediates microRNA regulation of muscle stem cell function / Cell Stem Cell 10:327~336
Bava, F. / 2013 / CPEB1 coordinates alternative 3prime]-UTR formation with translational regulation / Nature 495:121~125
Beaudoing, E. / 2000 / Patterns of variant polyadenylation signal usage in human genes / Genome Res 10:1001~1010
Beisang, D. / 2014 / Alternative polyadenylation regulates CELF1/CUGBP1 target transcripts following T cell activation / Gene 550:93~100
Boutet, S. / 2012 / Alternative polyadenylation mediates microRNA regulation of muscle stem cell function / Cell Stem Cell 10:327~336
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