지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.1
- 수록면
- 1 - 14 (14page)
이용수
초록· 키워드
오류제보하기
The glucocorticoid receptor (GR) can bind to DNA or RNA, eliciting transcriptional activation/repression or rapid messenger RNA (mRNA) degradation, respectively. Although GR-mediated transcriptional regulation has been well-characterized, the molecular details of rapid mRNA degradation induced by glucocorticoids are not yet fully understood. Here, we demonstrate that glucocorticoid-induced GR-mediated mRNA decay (GMD) takes place in the nucleus and the cytoplasm, acting on pre-mRNAs and mRNAs. We also performed cross-linking and immunoprecipitation coupled with high-throughput sequencing analysis for GMD factors (GR, YBX1, and HRSP12) and mRNA sequencing analysis to identify endogenous GMD substrates. Our comprehensive coupled with high-throughput sequencing and mRNA sequencing analyses reveal that a range of cellular transcripts containing a common binding site for GR, YBX1, and HRSP12 are preferential targets for GMD, suggesting possible new functions of GMD in various biological events.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
효소 및 초음파로 전처리한 가바쌀의 품질특성
한국생활과학회지
2023 .02
-
Deciphering the Genes for Taste Receptors for Fructose in Drosophila
Molecules and Cells
2017 .10
-
Development of mRNA Vaccines/Therapeutics and Their Delivery System
Molecules and Cells
2023 .01
-
MS2 Labeling of Endogenous Beta-Actin mRNA Does Not Result in Stabilization of Degradation Intermediates
Molecules and Cells
2019 .01
-
High-throughput sequencing analysis of differences in intestinal microflora between ulcerative colitis patients with different glucocorticoid response types
Genes & Genomics
2020 .01
-
Ovarian transcriptome profiles associated with sexual maturation in Pacific abalone (Haliotis discus hannai)
Genes & Genomics
2020 .01
-
분열효모에서 nab2 합성치사 돌연변이를 상보하는 SR 단백질이 mRNA 방출에 미치는 영향
미생물학회지
2024 .06
-
Simultaneous analysis of mRNA critical quality attribute using LC-MS
한국분석과학회 학술대회
2023 .05
-
Epigenetic and Glucocorticoid Receptor-Mediated Regulation of Glutathione Peroxidase 3 in Lung Cancer Cells
Molecules and Cells
2016 .08
-
COVID-19 mRNA Vaccine ; EG-COVID
한국분석과학회 학술대회
2022 .05
-
Effects of p-coumaric acid on microRNA expression profiles in SNU-16 human gastric cancer cells
Genes & Genomics
2020 .01
-
A newly developed capture-based sequencing panel for genomic assay of lung cancer
Genes & Genomics
2020 .01
-
분열효모에서 mep33/SPBC28F2.02 유전자가 mRNA 방출에 미치는 영향
미생물학회지
2024 .12
-
Bioinformatic and integrated analysis identifies an lncRNA–miRNA–mRNA interaction mechanism in gastric adenocarcinoma
Genes & Genomics
2021 .01
-
Gustatory Receptors Required for Avoiding the Tox-ic Compound Coumarin in Drosophila melanogaster
Molecules and Cells
2016 .04
-
Self-Amplifying mRNA (SAM): Next Generation Expression Platform and Its Application
한국미생물학회 학술대회논문집
2022 .10
-
mRNA Localization and Translation Mediated by Puf Protein Families
한국미생물학회 학술대회논문집
2020 .10
-
Genetic risk score combining six genetic variants associated with the cellular NRF2 expression levels correlates with Type 2 diabetes in the human population
Genes & Genomics
2019 .01
-
Alternative Polyadenylation of mRNAs: 3’-Untranslated Region Matters in Gene Expression
Molecules and Cells
2016 .04
-
[크로스로드] mRNA를 무력화할 수 있는 마이크로RNA
물리학과 첨단기술
2025 .02
최근 본 자료
댓글(0)
0