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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 747 - 755 (9page)
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Background In eukaryotic organisms, it has been well acknowledged that 3′ untranslated regions (3′ UTRs) of mRNA are actively involved in post-transcriptional regulations of gene expression. Although both shortening and lengthening of 3′ UTRs of specific candidate genes were explicitly documented to have functional consequences, landscape of 3′ UTR lengths in relation to evolutionary dynamics and biological meanings remains to be elucidated when large-scale data become available. Objectives The primary objective of this study was to revealed different inter- and intra-species patterns on length distribution of 3′ UTRs in comparison with 5′ UTRs and coding regions. Methods In the present study, we investigated 3′ UTR lengths in a highly curated set of 57,135 mRNA sequences among four well-studied and taxonomically diverse metazoan species (fruit fly, zebrafish, mouse and human). Results The average length ratio of 3′–5′ UTRs considerably increased from fruit fly (twofold) to human (fivefold). Moreover, genes can be characterized by the obviously different patterns of evolutionary change on 3′ UTR lengths. By utilizing the Gene Ontology annotations, genes with differential lengths of 3′ UTRs were suggested to have the divergent functional implications. In human, we further revealed that ubiquitously transcribed genes had higher median lengths of 3′ UTRs than the genes of tissue-restricted expressions. Conclusion We conducted a comprehensive analysis and provided an overview regarding 3′ UTRs biology of mRNAs in animals, whereas the mechanistic explanations of 3′ UTRs length variation in correlation to regulation of gene expression still remain to be further studied.
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참고문헌 (27)
참고문헌 신청
Akman HB / 2015 / 3′ UTR shortening and EGF signaling : implications for breast cancer / Hum Mol Genet 24:6910~6920
Berkovits BD / 2015 / Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization / Nature 522:363~367
Biswas A / 2014 / Scan for Motifs : a webserver for the analysis of post-transcriptional regulatory elements in the 3′ untranslated regions(3′ UTRs)of mRNAs / BMC Bioinform 15:174
Chatterjee S / 2009 / Role of 5′-and 3′-untranslated regions of mRNAs in human diseases / Biol Cell 101:251~262
Chen CY / 2012 / Lengthening of 3′UTR increases with morphological complexity in animal evolution / Bioinformatics 28:3178~3181
Berkovits BD / 2015 / Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization / Nature 522:363~367
Biswas A / 2014 / Scan for Motifs : a webserver for the analysis of post-transcriptional regulatory elements in the 3′ untranslated regions(3′ UTRs)of mRNAs / BMC Bioinform 15:174
Chatterjee S / 2009 / Role of 5′-and 3′-untranslated regions of mRNAs in human diseases / Biol Cell 101:251~262
Chen CY / 2012 / Lengthening of 3′UTR increases with morphological complexity in animal evolution / Bioinformatics 28:3178~3181
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