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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 814 - 820 (7page)
- DOI
- 10.14348/molcells.2015.0144
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초록· 키워드
오류제보하기
PinX1, a nucleolar protein of 328 amino acids, inhibits telomerase activity, which leads to the shortening of telomeres.
The C-terminal region of PinX1 is responsible for its nucleolar localization and binding with TERT, a catalytic component of telomerase. A fraction of TERT localizes to the nucleolus, but the role of TERT in the nucleolus is largely unknown. Here, we report a functional connection between PinX1 and TERT regarding PinX1 stability. The Cterminal of PinX1205-328, a nucleolar fragment, was much more stable than the N-terminal of PinX11-204, a nuclear fragment. Interestingly, PinX1 was less stable in TERTdepleted cells and more stable in TERT-myc expressing cells. Stability assays for PinX1 truncation forms showed that both PinX11-328 and PinX1205-328, nucleolar forms, were more rapidly degraded in TERT-depleted cells, while they were more stably maintained in TERT-overexpressing cells, compared to each of the controls. However, PinX11-204 was degraded regardless of the TERT status. These results reveal that the stability of PinX1 is maintained in nucleolus in the presence of TERT and suggest a role of TERT in the regulation of PinX1 steady-state levels.
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참고문헌 (31)
참고문헌 신청
Autexier, C. / 1998 / The structure and function of telomerase reverse transcriptase / Annu. Rev. Biochem 75:493~517
Avilion, A. A. / 1996 / Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues / Cancer Res 56:645~650
Banik, S. S. / 2004 / Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR / J. Biol. Chem 279:51745~51748
Beattie, T. L. / 1998 / Reconstitution of human telomerase activity in vitro / Curr. Biol 8:177~180
Bryan, T. M. / 1997 / Telomere dynamics and telomerase activity in in vitro immortalised human cells / Eur. J. Cancer 33:767~773
Avilion, A. A. / 1996 / Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues / Cancer Res 56:645~650
Banik, S. S. / 2004 / Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR / J. Biol. Chem 279:51745~51748
Beattie, T. L. / 1998 / Reconstitution of human telomerase activity in vitro / Curr. Biol 8:177~180
Bryan, T. M. / 1997 / Telomere dynamics and telomerase activity in in vitro immortalised human cells / Eur. J. Cancer 33:767~773
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