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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Effects on glutathione-related antioxidant parameters were examined after a chronic exposure of olive flounder, Paralichthys olivaceus to dietary 4-tert-octylphenol (4-tert-OP). Fish were fed diets containing 4-tert-OP at 0, 1, 5 and 10 mg/kg diet for 6 weeks. Antioxidant parameters examined were reduced glutathione (GSH) contents and enzyme activities of glutathione reductase (GR), glutathione S-transferase (GST) and glutathione peroxidase (GPx) in tissue homogenates of the liver, kidney and gill. It was observed that all parameters examined increased although there were some differences in dose responses and temporal patterns in the increase. GSH contents increased after exposure to 4-tert-OP in the three organs examined. However, the GSH increase was evident only after 4 weeks in the liver whereas it was elevated after 2 weeks in the kidney and gill. GR activity exhibited a significant increase in response to 4-tert-OP at 1 mg/kg in all three organs, however, its activity returned to control levels when exposed to 5 and 10 mg/kg. Hepatic GST activity showed an earlier increase at week 2 in contrast to the kidney and gill where they increased after 4 weeks of 4-tert-OP exposure. Temporal patterns in GPx activity changes to 4-tert-OP exposure were dissimilar among the organs: hepatic activity increased from week 2 through week 6; renal activity increased transiently at week 2; gill levels were higher through weeks 4 - 6. The results suggest that elevation of several GSH-related antioxidant parameters can be considered as evaluation criteria for 4-tert-OP-induced oxidative stress in a fish.
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참고문헌 (48)
참고문헌 신청
Aydoğan, M. / 2008 / The effect of vitamin C on bisphenol A, nonylphenol and octylphenol induced brain damages of male rats / Toxicology 249:35~39
Behne, D. / 1983 / Distribution of selenium and glutathione peroxidase in the rat / J. Nutr 113:456~461
Beresford, N. / 2000 / Issues arising when interpreting results from an in vitro assay for estrogenic activity / Toxicol. Appl. Pharmacol 162:22~33
Beutler, E / 1984 / A Manual of Biochemical Methods / Grune and Stratton :133
Bradford, M. M. / 1976 / A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72:248~254
Behne, D. / 1983 / Distribution of selenium and glutathione peroxidase in the rat / J. Nutr 113:456~461
Beresford, N. / 2000 / Issues arising when interpreting results from an in vitro assay for estrogenic activity / Toxicol. Appl. Pharmacol 162:22~33
Beutler, E / 1984 / A Manual of Biochemical Methods / Grune and Stratton :133
Bradford, M. M. / 1976 / A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72:248~254
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