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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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In the group of commonly prescribed β-blocker drugs, one of the enantiomers is generally relatively more active than the others. This study aims to develop a technique for the chiral analysis of select β-blockers based on proton nuclear magnetic resonance (<SUP>1</SUP>H-NMR) spectrometry. (S)-2-Tert-butyl-2-methyl-1,3-benzodioxole-4-carboxylic acid ((S)-TBMB) was synthesized and utilized as a chiral derivatizing agent. Pure β-blocker enantiomers were isolated from racemates by semi-preparative liquid chromatography prior to derivatization. The reaction time and concentration of (S)-TBMB were controlled to improve the derivatization procedure. No racemization was found during the analysis. High-performance liquid chromatography (HPLC) analysis was also performed for comparative purposes. High agreement between the NMR and HPLC methods was achieved in the determination of (R)-metoprolol in a standard solution of the (S) isomer.
목차
Abstract
1. Introduction
2. Experimental
3. Results and Discussion
4. Conclusions
References
참고문헌 (27)
참고문헌 신청
W. H. Frishman, A. Cheng-Lai and J. Nawarskas, ‘Current Cardiovascular Drugs’, 4th Ed., Current Medicine, Philadelphia, 2005.
W. S. Knowles, R. Noyori and K. B. Sharpless, ‘The Nobel Prize in Chemistry 2001’, https://www.nobelprize.org/prizes/chemistry/2001/summary/, Assessed 7 Apr 2020.
L. A. Nguyen, H. He and C. Pham-Huy, Int. J. Biomed. Sci., 2(2), 85-100 (2006).
U.S. Food and Drug Administration, ‘Development of New Stereoisomeric Drugs’, https://www.fda.gov/regulatoryinformation/search-fda-guidance-documents/developmentnew-stereoisomeric-drugs, Assessed 7 Apr 2020.
M. Ogrodowczyk, K. Dettlaff and A. Jelinska, Mini- Reviews Med. Chem., 16(1), 40-54 (2016).
W. S. Knowles, R. Noyori and K. B. Sharpless, ‘The Nobel Prize in Chemistry 2001’, https://www.nobelprize.org/prizes/chemistry/2001/summary/, Assessed 7 Apr 2020.
L. A. Nguyen, H. He and C. Pham-Huy, Int. J. Biomed. Sci., 2(2), 85-100 (2006).
U.S. Food and Drug Administration, ‘Development of New Stereoisomeric Drugs’, https://www.fda.gov/regulatoryinformation/search-fda-guidance-documents/developmentnew-stereoisomeric-drugs, Assessed 7 Apr 2020.
M. Ogrodowczyk, K. Dettlaff and A. Jelinska, Mini- Reviews Med. Chem., 16(1), 40-54 (2016).
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