지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한수의학회 Korean Journal of Veterinary Research(대한수의학회지) Korean Journal of Veterinary Research(구 대한수의학회지) 제57권 제3호
- 발행연도
- 2017.11
- 수록면
- 155 - 158 (4page)
이용수
초록· 키워드
오류제보하기
Surgical castration performed to reduce male-associated problems results in pain and microbial infections in male animals. Therefore, immunocontraception, which is mediated by the animal’s own antibodies against reproductive hormones, has been recommended as an alternative to surgical castration when considering the animal’s welfare. In this study, a new immunocontraceptive vaccine composed of six tandem copies of gonadotropin-releasing hormone (GnRH) fused to rat granulocyte-macrophage colony-stimulating factor (GM-CSF) was developed, and its efficacy was evaluated in male rats. Three different doses (10, 50, and 100 μg) of recombinant GM-CSF-GnRH protein were injected three times at intervals of two weeks into male rats. The rats vaccinated with three doses of GM-CSF-GnRH produced a significantly higher level of antibodies against GnRH than that in the negative control rats. Severe atrophy of gonads was observed in rats vaccinated with three doses of GM-CSF-GnRH but not in the negative control rats. The results reveal that the new GnRH vaccine conjugated with rat GM-CSF induces efficient immunocontraception in male rats. This formulation of the immunocontraceptive vaccine would be applicable to both domestic and pet male animals.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effectiveness of E. coli expressed STF2-GnRH vaccine as an immunocontraceptive in female cats
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Evaluation of infertility efficacy of the E. coli expressed STF2-GnRH vaccine in male cats
Journal of Veterinary Science
2019 .05
-
Gonadotropin-releasing hormone immunization and castration in male pigs: effects on growth, hormonal levels, antibody titer response, testicular function, back fat, and consumers` sensory perceptions
Korean Journal of Veterinary Research(대한수의학회지)
2017 .04
-
Impact of polystyrene microplastic exposure on lipid profile and oxidative stress status of male and female Wistar rats
Environmental Analysis Health and Toxicology
2022 .09
-
Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy
Diabetes and Metabolism Journal
2020 .01
-
COVID-19 Rapid Antigen Test Results in Preschool and School (March 2 to May 1, 2022)
Pediatric Infection and Vaccine
2024 .04
-
GnRH signaling in aging and stress physiology
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Four-Week Repeated Intravenous Dose Toxicity and Toxicokinetic Study of TS-DP2, a Novel Human Granulocyte Colony Stimulating Factor in Rats
Toxicological Research
2015 .12
-
Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review
Annals of Pediatirc Endocrinology & Metabolism
2020 .01
-
Inhibitory mechanism of ginsenoside Rh3 on granulocyte-macrophage colony-stimulating factor expression in UV-B-irradiated murine SP-1 keratinocytes
Journal of Ginseng Research
2020 .03
-
Toward the development of a one-dose classical swine fever subunit vaccine
Journal of Veterinary Science
2018 .05
-
Concurrent Gonadotropin-Releasing Hormone Agonist Administration with Chemotherapy Improves Neoadjuvant Chemotherapy Responses in Young Premenopausal Breast Cancer Patients
Journal of Breast Cancer
2015 .01
-
Evaluation of 28-day repeated oral dose toxicity of aluminum chloride in rats
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Evaluation of 28-day repeated oral dose toxicity of aluminum chloride in rats
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Time course analysis of cerebrospinal fluid in anesthetized rat
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Effects of Aging on Angiogenic and Muscle Growth-Related Factors in Naturally Aged Rat Skeletal Muscles
Annals of geriatric medicine and research
2020 .01
-
Process optimization for CRISPR/Cas9-mediated generation of transgenic rats
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Extended Culture of Bone Marrow with Granulocyte Macrophage-Colony Stimulating Factor Generates Immunosuppressive Cells
Immune Network
2018 .04
-
Gonadotropin releasing hormone antagonist administration for treatment of early type severe ovarian hyperstimulation syndrome: a case series
Obstetrics & Gynecology Science
2017 .01
-
Single-dose Intravenous Toxicology Testing of Daebohwalryeok Pharmacopuncture in Sprague-Dawley Rats
Journal of Pharmacopuncture
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-528-001375030