지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 453 - 458 (6page)
이용수
초록· 키워드
오류제보하기
Paclitaxel was isolated from the bark of the Pacific yew, Taxus brevifolia, and used as an anticancer agent. Paclitaxel prevents cancer cell division by inhibiting spindle fiber function, inducing cell death. A recent study demonstrated that paclitaxel binds to myeloid differentiation protein-2 of Toll-like receptor 4 and prevents the signal transduction of lipopolysaccharide (LPS). Paclitaxel converts immune cells hypo-responsive to LPS. In this study, we investigated whether paclitaxel can inhibit the phenotype and function of immune cells. To accomplish this, we used spleen cells, a major type of immune cell, LPS, a representative inflammatory agent and a mitogen for B lymphocytes. LPS profoundly increased the activation and cytokine production of spleen cells. However, paclitaxel significantly inhibited LPS-induced hyper-activation of spleen cells. Furthermore, we found that paclitaxel induced cell death of LPS-treated spleen cells. These results suggest that paclitaxel can inhibit the hyper-immune response of LPS in spleen cells via a variety of mechanisms. These findings suggest that paclitaxel can be used as a modulating agent for diseases induced by hyper-activation of B lymphocytes. Taken together, these results demonstrate that paclitaxel inhibits the function of spleen cells activated by LPS, and further induces cell death.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of Paclitaxel-loaded Nanoparticles on the Viability of Human Hepatocellular Carcinoma HepG2 Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Blockade of Autophagy Aggravates Endoplasmic Reticulum Stress and Improves Paclitaxel Cytotoxicity in Human Cervical Cancer Cells
Cancer Research and Treatment
2015 .01
-
Anti-inflammatory activity of doxorubicin on lipopolysaccharide-induced hyperactivation of spleen cells
예방수의학회지
2018 .06
-
Protein Phosphatase 1H, Cyclin-Dependent Kinase Inhibitor p27, and Cyclin-Dependent Kinase 2 in Paclitaxel Resistance for Triple Negative Breast Cancers
Journal of Breast Cancer
2020 .01
-
ATG5 knockout promotes paclitaxel sensitivity in drug-resistant cells via induction of necrotic cell death
The Korean Journal of Physiology & Pharmacology
2020 .01
-
Feasibility of using DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Arsenic Trioxide Promotes Paclitaxel Cytotoxicity in Resistant Breast Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Effect of sun ginseng potentiation on epirubicin and paclitaxel-induced apoptosis in human cervical cancer cells
Journal of Ginseng Research
2015 .07
-
Effect of sun ginseng potentiation on epirubicin and paclitaxel-induced apoptosis in human cervical cancer cells
Journal of Ginseng Research
2015 .01
-
Synergistic effect of Entolimod and Paclitaxel on cancer cells
한국실험동물학회 학술발표대회 논문집
2016 .08
-
유방암 환자에서 발생한 파클리탁셀 망막병증
Journal of Retina
2019 .01
-
Weekly versus 3-weekly paclitaxel in combination with carboplatin in advanced ovarian cancer: which is the optimal adjuvant chemotherapy regimen?
Journal of Gynecologic Oncology
2018 .01
-
Pretreatment of Low-Dose and Super-Low-Dose LPS on the Production of In Vitro LPS-Induced Inflammatory Mediators
Toxicological Research
2018 .01
-
Concurrent Chemoradiation with Weekly Paclitaxel and Cisplatin for Locally Advanced Cervical Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Non-convulsive seizure related to Cremophor EL™-free, polymeric micelle formulation of paclitaxel: a case report
Obstetrics & Gynecology Science
2018 .01
-
Involvement of GRP78 in the Resistance of Ovarian Carcinoma Cells to Paclitaxel
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Clinical Research on Albumin-Bound Paclitaxel-Based Chemotherapy for Advanced Esophageal Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Proton Pump Inhibition Enhances the Cytotoxicity of Paclitaxel in Cervical Cancer
Cancer Research and Treatment
2017 .07
-
A Single-Arm Phase II Study of Nab-Paclitaxel Plus Gemcitabine and Cisplatin for Locally Advanced or Metastatic Biliary Tract Cancer
Cancer Research and Treatment
2024 .04
-
Lipopolysaccharide에 의해 과활성화된 마우스 비장세포에서 Enrofloxacin의 조절작용
Korean Journal of Veterinary Research(대한수의학회지)
2019 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-528-001365456