Concurrent Chemoradiation with Weekly Paclitaxel and Cisplatin for Locally Advanced Cervical Cancer

Kalaghchi, Bita; Abdi, Robab; Amouzegar-Hashemi, Farnaz; Esmati, Ebrahim; Alikhasi, Afsaneh

추천

검색

자료유형: 학술저널

저자정보: Kalaghchi, Bita (Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences) Abdi, Robab (Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences) Amouzegar-Hashemi, Farnaz (Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences) Esmati, Ebrahim (Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences) Alikhasi, Afsaneh (Radiology Department, Tehran University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제3호

발행연도: 2016.1

수록면: 287 - 291 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Cervical cancer is one of the most common gynecological cancers in Iranian women. This study was initiated to assess whether the combination of paclitaxel and cisplatin with radiation might feasible for these patients. The aim was to assess tumor response and toxicity of weekly cisplatin and paclitaxel along with radiotherapy in the treatment of cervical cancer. Women with primary untreated squamous cell carcinoma of the cervix with FIGO stages IB2 to IIIB were treated with weekly injections of cisplatin 30 mg/m2 and paclitaxel 35 mg/m2 for 5-6 weeks along with radiotherapy. A total of 25 patients were enrolled in this study who completed the intended treatment. Disease was assessed prior to treatment by pelvic examination and contrast enhanced MRI of the abdomen and pelvis. Response was assessed 1 month after completion of treatment by physical examination and 3 months after also by MRI.Toxicity was assessed and was graded using RTOG grading. There was a complete response rate of 84% after 3 months. The major toxicity was grade 1 and 2 anemia (92%). The mean duration of treatment was 58 days. In conclusion, combination chemotherapy with cisplatin and paclitaxel along with radiotherapy in patients with locally advanced squamous cell carcinoma of cervixwas well tolerated, in contrast to other studies, but it seems that there was no increase in tumor response and progression free survival with this treatment regimen.

#Cervical cancer #locally advanced #concurrent chemoradiation #paclitaxel #cisplatin

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

Kalaghchi, Bita

소속기관 Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences