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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 107 - 113 (7page)
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Geldanamycin is a macrocyclic heat shock protein 90 (HSP90) inhibitor that suppresses cancer cell proliferation.
Since geldanamycin also promotes the heat shock response (HSR) in cells, this compound is used as a chemical inducer of the HSR in Arabidopsis. Although many types of HSP90 inhibitors that are different from the macrocyclic types have been developed in pharmaceutical research, non-macrocyclic HSP90 inhibitors have not been investigated in terms of whether they can induce the HSR in plants. Here, we determined the HSR-inducing activities in Arabidopsis of 10 non-macrocyclic HSP90 inhibitors including 2 benzamide derivatives, 3 purine derivatives, and 5 resorcinol derivatives. Among the tested inhibitors, PU-H71, which is a purine derivative, showed the highest HSR-inducing activity. The activity of PU-H71 was significantly higher than that of geldanamycin. The application of PU-H71 induced the HSR in all Arabidopsis seedlings. The HSP17.6C-CI and HSP70 proteins accumulated after the treatment with PU-H71. The seedlings treated with PU-H71 maintained more chlorophyll than the control seedlings after the heat stress. These results suggest that the purine-derivative HSP90 inhibitor PU-H71 enhanced the heat tolerance of Arabidopsis by promoting the HSR in the plant.
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참고문헌 (30)
참고문헌 신청
Allakhverdiev SI / 2008 / Heat stress: an overview of molecular responses in photosynthesis / Photosynth Res 98:541~550
Al-Whaibi MH / 2011 / Plant heat-shock proteins: a mini review / J King Saud Univ Sci 23:139~150
Bita CE / 2013 / Plant tolerance to high temperature in a changing environment: scientific fundamentals and production of heat stress-tolerant crops / Front Plant Sci 4:273
Blagg BS / 2006 / Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation / Med Res Rev 26:310~338
Cle´ment M / 2011 / The cytosolic/nuclear HSC70 and HSP90 molecular chaperones are important for stomatal closure and modulate abscisic acid-dependent physiological responses in Arabidopsis / Plant Physiol 156:1481~1492
Al-Whaibi MH / 2011 / Plant heat-shock proteins: a mini review / J King Saud Univ Sci 23:139~150
Bita CE / 2013 / Plant tolerance to high temperature in a changing environment: scientific fundamentals and production of heat stress-tolerant crops / Front Plant Sci 4:273
Blagg BS / 2006 / Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation / Med Res Rev 26:310~338
Cle´ment M / 2011 / The cytosolic/nuclear HSC70 and HSP90 molecular chaperones are important for stomatal closure and modulate abscisic acid-dependent physiological responses in Arabidopsis / Plant Physiol 156:1481~1492
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