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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 174 - 179 (6page)
- DOI
- https://doi.org/10.13041/jpvm.2017.41.4.174
이용수
초록· 키워드
오류제보하기
The purpose of this study is to set the method condition of the DPRA in Korea throughout reproducibility study.
We conducted intra-lab (triplicate) and inter-lab (three labs of CRI, KTR and CU) validation using 20 chemicals (10 chemicals for the proficiency test listed in the OECD test guideline 442C and an additional 10 more chemicals from reference papers).
The data from all three labs met the acceptance criteria. Upon intra-lab validation, two positive chemicals out of 20 total chemicals showed false negative, and one negative chemical showed false positive. In inter-lab validation of three labs, the sensitivity data were 83, 83 and 88% each, and the specificity data was 100, 100 and 88% each. So the accuracy of the three labs was equal to 90%. During these studies, we also checked and improved various limitations that arose. Taken together, the results indicated that the DPRA proposed by OECD test guideline 442C is expected to become a well-established method under Korean GLP applied system.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Ahlfors SR / 2003 / Reactivity of contact allergenic haptens to amino acid residues in a model carrier peptide, and characterization of formed peptidehapten adducts / Skin Pharmacol Appl Skin Physiol 16:59~68
Aleksic M / 2008 / Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins / Toxicol In Vitro 22:1169~1176
Bauch C / 2011 / Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals / Toxicol In Vitro 25:1162~1168
Buehler EV / 1965 / Delayed contact hypersensitivity in the guinea pig / Arch Dermatol 91:171~177
Cho SA / 2014 / Method for detecting the reactivity of chemicals towards peptides as an alternative test method for assessing skin sensitization potential / Toxicol Lett 225:185~191
Aleksic M / 2008 / Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins / Toxicol In Vitro 22:1169~1176
Bauch C / 2011 / Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals / Toxicol In Vitro 25:1162~1168
Buehler EV / 1965 / Delayed contact hypersensitivity in the guinea pig / Arch Dermatol 91:171~177
Cho SA / 2014 / Method for detecting the reactivity of chemicals towards peptides as an alternative test method for assessing skin sensitization potential / Toxicol Lett 225:185~191
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