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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 178 - 178 (1page)
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Some chemicals can bind to skin proteins and induce sensitization. Direct peptide reactivity assay (DPRA) listed in the OECD guideline is an alternative method to evaluate the skin sensitization, by assessing a substance"s reaction to peptides. Newly modified spectrophotometric method for skin sensitization evaluation (spectro-DPRA) in Korea can improve some defect of DPRA. Pre-validation studies for spectro-DPRA were conducted at three institutions (AP, KTR, and KCL) to exam the transferability and proficiency, within and between laboratory reproducibility, and predictive ability based on GLP principle. All organizations confirmed more than 90% of agreements for the proficiency evaluation using ten chemical substances. Within the laboratory reproducibility evaluation, the agreement rate between the three tests performed by each institution was confirmed as 90% for AP, 100% for KTR, and 100% for ... 전체 초록 보기
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